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MetabolomicsGCN2 regulates mitochondrial OXPHOS in HSPCs under proliferation conditions.
Not available
ORGANISM(S): Mus musculus 
ST002123 | MetabolomicsWorkbench
GenomicsTranscriptome analysis of HLA-DR(+) HSPCs and HLA-DR(-) HSPCs in aplastic anemia patients
Transcriptome analysis of HLA-DR(+) HSPCs and HLA-DR(-) HSPCs in aplastic anemia patients
PRJNA761999 | ENA
GenomicsHistone chromatin modifications in control and Med12-deficient mouse HSPCs
Using iChIP, we map H3K27Ac, H3K4me3 and H3K4me1 in small populations (HSPCs) in the presence or absence of Med12 and identify affected super-enhancers. iChIP was performed using previously published protocols (Lara-Astiaso et al, 2014 Immunogenetics. Chromatin state dynamics during blood formation ...
ORGANISM(S): Mus musculus 
2016-08-25 | E-GEOD-76052 | biostudies-arrayexpress
TranscriptomicsRole of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies [RNA-seq]
Development of the hematopoietic system is dynamically controlled by the interplay of transcriptional and epigenetic networks to determine cellular identity. Those networks are critical for homeostasis and frequently dysregulated in leukemias. We identified histone demethylase Kdm2b as a critical re...
ORGANISM(S): Mus musculus 
2016-02-22 | E-GEOD-70728 | biostudies-arrayexpress
TranscriptomicsJarid2 regulates hematopoietic stem cell function by acting with Polycomb Repressive Complex 2
Polycomb Repressive Complex 2 (PRC2) has been shown to play a key role in hematopoietic stem and progenitor cell (HSPC) function. Analyses of mouse mutants harboring deletions of core components have implicated PRC2 in fine-tuning multiple pathways that instruct HSPC behavior, yet how PRC2 is target...
ORGANISM(S): Mus musculus 
2015-04-02 | E-GEOD-60808 | biostudies-arrayexpress
GenomicsMouse E11 WT and GATA2 heterozygous HSPCs
Mouse E11 WT and GATA2 heterozygous HSPCs
PRJEB59592 | ENA
ProteomicsFoetal and adult HSPCs - Comprehensive Proteomic Characterization of Ontogenic Changes in Hematopoietic Stem and Progenitor Cells
Haematopoietic stem and progenitor cells (HSPCs) in the foetus and adult possess distinct molecular landscapes that regulate cell fate and change their susceptibility to initiation and progression of haematopoietic malignancies. The proteomic programs that govern these differences remain elusive. In...
ORGANISM(S): Mus musculus (Mouse) 
2017-12-12 | PXD006876 | Pride
Haematopoiesis Mouse Adult bone marrow Foetal liver 
TranscriptomicsRNA-seq of CN, CN/AML, and CN/AML BAALC KO iPSCs-derived HSPCs
Severe congenital neutropenia (CN) is a pre-leukemia syndrome that, in the majority of patients, is caused by heterogeneous ELANE mutations encoding neutrophil elastase (NE). To study leukemogenesis associated with CN we generated CN and CN/AML patient-specific induced pluripotent stem cells (iPSCs)...
ORGANISM(S): Homo sapiens 
2021-03-08 | E-MTAB-10162 | biostudies-arrayexpress
GenomicsHomo sapiens isolate:CD34+ HSPCs
Off-target deep sequencing of FLT3, CD123, KIT epitope-edited CD34+ HSPCs
PRJNA986845 | ENA
GenomicsTranscriptome of CBX7 and CBX8 overexpressing CD34+ HSPCs
Transcriptome of CBX7 and CBX8 overexpressing CD34+ HSPCs
PRJEB22831 | ENA
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