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GenomicsEpigenomic landscape during organ formation in human early embryos
Here we present the whole genome ChIP-Seq analyses of a wide variety of histone marks, H3K27ac, H3K4me1, H3K4me3, and H3K27me3 in the brain, heart, and liver, along with the RNA-seq data of these organs of early human embryos 12 weeks after gestation. In total, brain, heart, and liver of early human...
ORGANISM(S): Homo sapiens 
2016-07-05 | E-GEOD-63634 | biostudies-arrayexpress
GenomicsTet and TDG Mediate DNA Demethylation Essential for MET in Somatic Cell Reprogramming
Tet-mediated DNA oxidation is a new type of epigenetic modification in mammals and its role in the regulation of cell fate transition remains poorly understood. Here, we derive mouse embryonic fibroblasts (MEFs) deleted in all three Tet genes and examine their capability to be reprogrammed into iPS ...
ORGANISM(S): Mus musculus 
2014-02-19 | E-GEOD-52741 | biostudies-arrayexpress
TranscriptomicsTracing the expression of circular RNAs in human preimplantation embryos
We systematically analyzed transcriptome in individual human oocytes and preimplantation embryos with a new single-cell RNA seq method we recently developed. We sequenced individual single cells or embryos at seven consecutive stages (mature oocytes, zygotes, 2-cell, 4-cell, 8-cell embryos, morulae,...
ORGANISM(S): Homo sapiens 
2016-05-13 | E-GEOD-71318 | biostudies-arrayexpress
GenomicsActive Demethylation of Both Maternal and Paternal Genomes in Mouse Zygotes
The epigenomes of mammalian sperm and oocytes, characterized by gamete-specific 5-methylcytosine (5mC) patterns, are reprogrammed in early embryogenesis to establish full developmental potential. It is broadly accepted that the paternal genome is actively demethylated in the zygote while the materna...
ORGANISM(S): Mus musculus 
2016-09-01 | E-GEOD-60777 | biostudies-arrayexpress
GenomicsActive and Passive Demethylation of Male and Female Pronuclear DNA in the Mammalian Zygote
The epigenomes of mammalian sperm and oocytes, characterized by gamete-specific 5-methylcytosine (5mC) patterns, are reprogrammed during early embryogenesis to establish full developmental potential. Previous studies have suggested that the paternal genome is actively demethylated in the zygote whil...
ORGANISM(S): Mus musculus 
2014-09-11 | E-GEOD-56650 | biostudies-arrayexpress
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