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Ipomoeassin F (Ipom-F) is a natural compound that exhibits a potent cytotoxic effect on triple-negative breast cancer (TNBC) cells. The mechanism underlying this selective potency remains unclear. To elucidate this mechanism, we analyzed the proteome profiles of the TNBC MDA-MB-231 cells after expos...
ORGANISM(S): Homo sapiens (Human) 
2025-09-15 | PXD060444 | Pride
Lappaol F, a natural lignin isolated from the seeds of Arctium lappa L., was previously shown to have an inhibitory effect on tumour cells and might be a promising drug candidate for cancer chemotherapy. In the present study, human colon cancer cell line SW480 was treated with Lappaol F, and quantit...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD017872 | Pride
The ability of male reproduction is seriously dependent on Sertoli cells. However, the mechanisms governing the functional integrity of Sertoli cells remained largely unexplored. Tyrosine phosphatase protein Shp2 is expressed in germ, Leydig and Sertoli cells of mice testes. But the physiological ro...
ORGANISM(S): Mus musculus 
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