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ProteomicsANGPTL4 binds to leptin receptor to regulate ectopic bone formation and fat metabolism
Leptin protein was thought to be unique to leptin receptor (LepR), but the phenotypes of mice with mutation in LepR (db/db) and leptin (ob/ob) are not identical, and the cause remains unclear. Here, we show that db/db, but not ob/ob mice had defect in tenotomy-induced heterotopic ossification (HO), ...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD043087 | Pride
Leptin receptor  angptl4  heterotopic ossification  fat metabolism 
ProteomicsKu80 lysine crotonylation conversion to SUMOylation facilitates DNA non-homologous end joining and cellular resistance to radiation
A DNA double-strand break (DSB) is the most serious DNA damage and is also the principal molecular basis of radiotherapy. Upon DNA damage, the Ku80 is recruited and forms a critical DNA-PK complex at the DSB sites with Ku70 and the catalytic subunit (DNA-PKcs) to initiate DNA repair. How DNA-PK is a...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD061039 | Pride
Dna double-strand break repair  ku80  crotonylation  sumoylation  dna-pk holoenzyme assembly  radioresistance 
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