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TranscriptomicsTranscriptomic profiling of L-rhamnose utilization in Lmo0753 deletion mutant of Listeria monocytogenes EGDe from human foodborne outbreak associated lineage LII
Among the three major genetic lineages of L. monocytogenes (i.e. LI, LII, and LIII), LI and LII are predominantly associated with foodborne listeriosis outbreaks, whereas LIII is rarely implicated in human infections. In a previous study, we identified a Crp/Fnr family transcription factor lmo0753 t...
ORGANISM(S): Listeria monocytogenes 
2013-07-17 | E-GEOD-47721 | biostudies-arrayexpress
MetabolomicsCyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs (Murine and human plasma quantitative L-arginine and methylarginines UPLC-MS/MS assay)

BACKGROUND: Large-scale, placebo-controlled trials established that nonsteroidal anti-inflammatory drugs confer a cardiovascular hazard: this has been attributed to depression of cardioprotective products of cyclooxygenase (COX)-2, especially prostacyclin. An alternative mechanis...

2019-08-22 | MTBLS685 | MetaboLights
MetabolomicsMethionine Intervention Induces PD-L1 Expression to Enhance the Immune Checkpoint Therapy Response in MTAP-deleted Osteosarcoma
Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomics and transcriptomics analyses, we have identified a subgroup of OS with methylthioadenosine phosphorylase (MTAP) deletion, which contributes to ICT r...
2026-06-09 | MTBLS11985 | MetaboLights
UnknownThe complete chloroplast genome of Bupleurum marginatum var. stenophyllum (H. Wolff) Shan & Yin Li (Apiaceae), a new substitution for Chinese medicinal material, Bupleuri Radix (Chai hu).
Not available
S-EPMC7872558 | biostudies-literature
GenomicsRNAi promotes heterochromatic silencing through replication-coupled release of RNA pol II (ChIP-seq)
Heterochromatin comprises tightly compacted repetitive regions of eukaryotic chromosomes. The inheritance of heterochromatin through mitosis requires RNA interference (RNAi), which guides histone modification 1 during the DNA replication phase of the cell cycle2. Here, we show that the alternating a...
ORGANISM(S): Schizosaccharomyces pombe 
2011-07-29 | E-GEOD-31016 | biostudies-arrayexpress
TranscriptomicsGenome-wide Profiling of DNA Replication Timing in pombe.
DNA replication is initiated at multiple sites or origins enriched with AT-rich sequences at various times during the S-phase. While current studies of genome-wide DNA replication profiles have focused on the timing of replication and the location of origins, the efficiency of replication/firing at...
ORGANISM(S): Schizosaccharomyces pombe 
2007-08-14 | E-GEOD-6977 | biostudies-arrayexpress
UnknownSelf-organized hetero-nanodomains actuating super Li+ conduction in glass ceramics.
Not available
S-EPMC9905078 | biostudies-literature
ProteomicsAn aspartyl pseudoprotease dominates the secretory hydrolase landscape of the skin commensal Malassezia in situ
Malassezia globosa is abundant and prevalent on sebaceous areas of the human skin. Genome annotation reveals that M. globosa possesses a repertoire of secreted hydrolytic enzymes relevant for lipid and protein metabolism on the skin. In-gel proteomics identifies a predicted aspartyl protease, MGL_33...
ORGANISM(S): Cellular Organisms 
2023-11-23 | PXD042508 | JPOST Repository
MetabolomicsResearch on vaccine immunity based on gut microbiota and metabolomics The impact of pseudorabies virus infection

Pseudorabies virus infection causes intestinal flora disorder in animals, leading to diarrhea. To explore the effect of inactivated pseudorabies vaccine immunization on pseudorabies virus infection, this study sequenced the serum metabolome and intestinal microbiota of Hu sheep, analyzed their di...

2025-09-03 | MTBLS12933 | MetaboLights
UnknownTackling realistic Li+ flux for high-energy lithium metal batteries.
Not available
S-EPMC9481556 | biostudies-literature
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