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ProteomicsInvestigation of the aging process of C. elegans using integrated quantitative proteomics and N-glycoproteomics
N-glycosylation, a highly diverse and abundant post-translational modification, critically regulates organismal aging. Leveraging the Caenorhabditis elegans (C. elegans) model, which exhibits distinctive N-glycosylation features including highly fucosylated core structures, bisecting β1,4-galactose,...
ORGANISM(S): Caenorhabditis elegans 
2026-09-14 | PXD067150 | Pride
Aging process Nanolc-esi-ms/ms N-glycosylation Caenorhabditis elegans 
UnknownXiaoyu Xiezhuo Drink Protects against Ischemia-Reperfusion Acute Kidney Injury in Aged Mice through Inhibiting the TGF-β1/Smad3 and HIF1 Signaling Pathways.
Not available
S-EPMC8449228 | biostudies-literature
TranscriptomicsTranscription profiling of IFN-gamma transcriptional responses in control and IFN-gamma primed primary human macrophages
IFN-gamma transcriptional responses in control and IFN-gamma primed primary human macrophages
ORGANISM(S): Homo sapiens 
2007-09-01 | E-GEOD-1925 | biostudies-arrayexpress
MetabolomicsTranscriptomic and metabolomic analyses reveal the differential accumulation of phenylpropanoids and terpenoids in hemp autotetraploid and its diploid progenitor

Background

Cannabis sativa, a dioecious plant that has been cultivated worldwide for thousands of years, is known for its secondary metabolites, especially cannabinoids, which possess several medicinal effects. In this study, we investigated the autopolyploidization effects on the biosynthes...
2023-09-21 | MTBLS6032 | MetaboLights
ProteomicsA comprehensive landscape of human organ N-glycoproteome
N-glycosylation, as a common post-translational modification with enormous structures, plays key roles in protein folding, cellular recognition and signaling pathways. State-of-the-art mass spectrometry-based N-glycoproteomics has enabled deep N-glycoproteome characterization of various human organs...
ORGANISM(S): Homo sapiens (Human) 
2026-05-13 | PXD070547 | Pride
Tissue Human N-glycosylation Profile 
MetabolomicsSingle-cell metabolic fingerprints discover a cluster of circulating tumor cells with distinct metastatic potential

Circulating tumor cells (CTCs) are recognized as direct seeds of metastasis. However, CTC count may not be the 'best' indicator of metastatic risk because their heterogeneity is generally neglected. In this study, we develop a molecular typing system to predict colorectal cancer metastasis potent...

2023-08-21 | MTBLS5028 | MetaboLights
MetabolomicsClinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats.

OBJECTIVE: To observe the clinical efficacy and safety of Yiqi Yangxue formula (YQYXF) on knee osteoarthritis (KOA), and to explore the underlying therapeutic mechanism of YQYXF through endogenous differential metabolites and their related metabolic pathways.

METHOD...

2024-03-25 | MTBLS5667 | MetaboLights
GenomicsExamination of whole genome DNA methylation status of two chicken breeds
We report the genome-wide DNA methylation mapping of chicken by methylated DNA immunoprecipitation following by highthroughput sequencing, and the gene expression profile of chicken by RNA-seq. For meDIP-seq, about 17,202,074 to 27,501,760 reads were generated for the tissue and liver tissues of the...
ORGANISM(S): Gallus gallus 
2010-04-02 | E-GEOD-21167 | biostudies-arrayexpress
ProteomicsHigh-quality and robust protein quantification in large clinical cohort of serum samples with IonStar
Robust, reliable quantification of large sample cohorts is often essential for meaningful clinical or pharmaceutical proteomics investigations, but it is technically challenging. When analyzing very large numbers of samples, isotope labeling approaches may suffer from substantial batch effects; and...
ORGANISM(S): Homo sapiens (Human) 
2023-10-12 | PXD036822 | Pride
Large-cohort clinical study  quantitative proteomics  ionstar  liquid chromatography-mass spectrometry  high-resolution mass spectrometry 
ProteomicsLC-MS/MS identification of BMAL1 interaction proteins
Advances in circadian research revealed an intricate relationship between aging and circadian rhythms. However, whether and how the circadian machinery contribute to stem cell aging, especially in primates, remains poorly understood. In this study, we investigated the role of BMAL1, the only non-red...
ORGANISM(S): Homo sapiens (Human) 
2022-03-18 | PXD030570 | Pride
Bmal1 aging 
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