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ProteomicsNS7a of SADS-CoV promotes viral infection via inducing apoptosis to suppress Type III interferon production
SADS-CoV is a newly discovered swine coronavirus with potential cross-species transmission risk. Although SADS-CoV-induced host cell apoptosis and attenuated innate immunity has been established, the relation between apoptosis and innate immunity remain obscure. Here, we demonstrate that infection o...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2025-05-06 | PXD047032 | Pride
Viral replication Swine acute diarrhea syndrome virus (sads-cov) Ns7a Apoptosis Apoptosis inducing factor mitochondria associated 1 (aifm1) Ifn-λ 
ProteomicsHSP60-mediated UPRmt overactivation drives triptolide-induced Hepatocellular lipoapoptosis
This study aims to investigate the role of excessive activation of the mitochondrial unfolded protein response (UPRmt) in TP-induced liver injury and to elucidate the mechanism by which HSP60 mediates this process in regulating lipid metabolism disorders.
ORGANISM(S): Mus Musculus 
2026-01-08 | PXD072797 |
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