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TranscriptomicsDestabilization of Nucleophosmin mRNA by the HuR/KSRP complex is required for muscle fiber formation
HuR promotes myogenesis by stabilizing MyoD, Myogenin and p21 mRNAs during the fusion step of muscle cells to form myotubes. Here we show that HuR, via a novel mRNA destabilizing activity, promotes the early steps of myogenesis by reducing the expression of the cell cycle promoter nucleophosmin (NPM...
ORGANISM(S): Mus musculus 
2014-04-26 | E-GEOD-57113 | biostudies-arrayexpress
UnknownThe small molecule raptinal can simultaneously induce apoptosis and inhibit PANX1 activity.
Not available
S-EPMC10858176 | biostudies-literature
TranscriptomicsA Distinct Reactive Oxygen Species Profile confers Chemoresistance in Glioma-Propagating Cells and Associates with Patient Survival Outcome
Aims: We explore the role of elevated O2-:H2O2 ratio as a prosurvival signal in glioma-propagating cells (GPCs). We hypothesize that depleting this ratio sensitizes GPCs to apoptotic triggers. Results: We observed that elevated O2-:H2O2 ratio conferred enhanced resistance in GPCs, and depletion of t...
ORGANISM(S): Homo sapiens 
2013-03-13 | E-GEOD-32335 | biostudies-arrayexpress
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