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MetabolomicsTherapeutic effects of traditional Chinese medicine compound Hua-Feng-Dan in a rat model of ischemic stroke involve renormalization of gut microbiota

Hua-Feng-Dan is a traditional Chinese medicine compound used to treat ischemic stroke, but little is known about its therapeutic mechanism. This study explored whether and how the mechanism involves readjustment of gut microbiota. Rats were subjected to middle cerebral artery occlusion as a model...

2025-01-06 | MTBLS10818 | MetaboLights
ProteomicsMeasurement of site-specific H2O2-sensitivity and identification of sulfenic acid modification of CLOCK cysteines
In vitro H2O2-sensitivity of CLOCK cysteines was measured with a quantitative chemoproteomic approach termed as QTRP (Quantitative Thiol Reactivity Profiling) as previously reported. In brief, 5 μg of recombinant CLOCK proteins were reduced with 1 mM DTT for 30 min at room temperature. After reactio...
ORGANISM(S): Homo Sapiens Mus Musculus 
2019-08-31 | PXD015266 |
Transcriptomicstomato salt response
Wild halophytic tomato has long been considered as an ideal gene donor for improving salt tolerance in tomato cultivars. Here, a wild tomato genotype, Solanum pimpinellifolium M-bM-^@M-^XPI365967M-bM-^@M-^Y is significantly more salt-tolerant than a cultivar, Solanum lycopersicom M-bM-^@M-^Xmoneymak...
ORGANISM(S): Solanum lycopersicum 
2010-05-31 | E-GEOD-16401 | biostudies-arrayexpress
MetabolomicsCharacterization of Constituents with Potential Anti-Inflammatory Activity in Chinese Lonicera Species by UHPLC-HRMS Based Metabolite Profiling
This study centered on detecting potentially anti-inflammatory active constituents in ethanolic extracts of Chinese Lonicera species by taking an UHPLC-HRMS-based metabolite profiling approach. Extracts from eight different Lonicera species were subjected to both UHPLC-HRMS analysis and to pharmacol...
2022-11-17 | MTBLS3112 | MetaboLights
MetabolomicsMicrobiota Reprogramming Driven by 7,8-Dihydroxyflavone Potentiates Xanthine Oxidase to Mitigate Hyperuricemia
Hyperuricemia (HUA), primarily driven by xanthine oxidase (XO)-mediated uric acid production, presents substantial challenges to both human health and livestock productivity. While conventional XO inhibitors are effective in mitigating HUA, they are often linked to severe adverse effects. In this st...
2026-04-29 | MTBLS14398 | MetaboLights
UnknownTransfemoral Occlusion of Doubly Committed Subarterial Ventricular Septal Defect Using the Amplatzer Duct Occluder-II in Children.
Not available
S-EPMC9039183 | biostudies-literature
MetabolomicsUnraveling the Heterogeneity of Hyperuricemia Using Untargeted Metabolomics and Statistical Modeling

Background. Hyperuricemia is the second most prevalent metabolic disorder globally and exhibits pronounced heterogeneity in clinical practice. Only about 10% of individuals with asymptomatic hyperuricemia (HUA) progress to gout, yet the lack of specific biomarkers and precise therapeutic targets ...

2025-10-05 | MTBLS13094 | MetaboLights
ProteomicsZIKV-infected human NPCs LC-MS
In this study, proteomic analysis on ZIKV-infected primary human fetal neural progenitor cells (NPCs) revealed that virus infection altered levels of cellular proteins involved in NPC proliferation, differentiation and migration.
ORGANISM(S): Homo sapiens (Human) 
2018-06-25 | PXD009343 | Pride
Human npcs Zikv infection 
TranscriptomicsmiRNA expression of human samples of hepatoblastoma (HB) and normal and fetal liver
Forty-nine hepatoblastoma (HB) tumor specimens were profiled on a microarray containing 250human miRNA, in order to identify miR classifiers that could discriminate HBs with diverse prognosis, and to get insight on the functional mechanisms in which miRNAs are involved. Hierarchical unsupervised clu...
ORGANISM(S): Homo sapiens 
2011-07-08 | E-GEOD-20971 | biostudies-arrayexpress
TranscriptomicsTranscriptional Profile of the Shigella flexneri Response to Berberine
Berberine is a natural isoquinoline alkaloid found in Chinese medicinal herbs which is active against a variety of microbial infections. To examine the potential effects of berberine on Shigella flexneri, a whole-genome DNA microarray was constructed and transcriptome analysis of the cellular respon...
ORGANISM(S): Shigella flexneri 
2012-03-10 | E-GEOD-16714 | biostudies-arrayexpress
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