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MetabolomicsTherapeutic effects of traditional Chinese medicine compound Hua-Feng-Dan in a rat model of ischemic stroke involve renormalization of gut microbiota

Hua-Feng-Dan is a traditional Chinese medicine compound used to treat ischemic stroke, but little is known about its therapeutic mechanism. This study explored whether and how the mechanism involves readjustment of gut microbiota. Rats were subjected to middle cerebral artery occlusion as a model...

2025-01-06 | MTBLS10818 | MetaboLights
TranscriptomicsTemporally defined neocortical translation and polysome assembly is determined by the RNA-binding protein, Hu antigen R
Precise spatiotemporal control of mRNA translation machinery is essential to proper development of highly complex systems like the neocortex. Here, we show that an RNA-binding protein, Hu antigen R (HuR), regulates both neocorticogenesis and specificity of neocortical translation machinery in a deve...
ORGANISM(S): Mus musculus 
2014-08-25 | E-GEOD-50809 | biostudies-arrayexpress
UnknownDetermination and analysis of monosaccharides in Polygonatum cyrtonema Hua polysaccharides from different areas by ultra-high-performance liquid chromatography quadrupole trap tandem mass spectrometry.
Not available
S-EPMC9292008 | biostudies-literature
TranscriptomicsThe RNA-binding protein HuR coordinates global changes in gene expression during patterning of early peripheral nerves
Identify mRNA targets of the RNA-binding protein HuR in vivo during Schwann cell development using RIP-chip analysis. IP protocol of endogenous mRNA-transfected HuR complexes was performed as described in Keene et al. (2006). In brief, 500 mg of whole-cell lysate obtained from a pool of NB or P5 sci...
ORGANISM(S): Mus musculus 
2012-01-19 | E-MEXP-3519 | biostudies-arrayexpress
TranscriptomicsHuR differentially regulates unique subsets of mRNAs in estrogen receptor negative and positive breast cancer
Analysis of RNA immunoprecipitation of HuR, a RNA binding protein (RBP), in breast cancer cell lines. This approach, utilizing RNA immunoprecipitation hybridized to microarray (RIP-Chip), provides global identification of putative endogenous mRNA targets of different RBPs. HuR is an RBP that binds ...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-17820 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of human anaplastic meningioma IOMM-Lee cells following silencing of HuR (Human antigen R) gene expression by siRNA
The human anaplastic meningioma IOMM-Lee cells were cultured in Dulbecco’s modified Eagle’s medium (Life Technologies, Carlsbad, California, USA) supplemented with 10% fetal bovine serum, 100 U/ml penicillin, and 100 mg/ml streptomycin, at 37°C in 20% O2 (5% CO2). HuR silencing was achieved by ...
ORGANISM(S): Homo sapiens 
2017-07-01 | E-MTAB-4999 | biostudies-arrayexpress
TranscriptomicsAdenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation
Adenosine-to-inosine (A-to-I) RNA editing, which is catalyzed by a family of adenosine deaminase acting on RNA (ADAR) enzymes, is important in the epitranscriptomic regulation of RNA metabolism. However, the role of A-to-I RNA editing in vascular disease is unknown. Here we show that cathepsin S mRN...
ORGANISM(S): Homo sapiens 
2016-09-05 | E-GEOD-60217 | biostudies-arrayexpress
UnknownBetalain biosynthesis in red pulp pitaya is regulated via HuMYB132: a R-R type MYB transcription factor.
Not available
S-EPMC9837905 | biostudies-literature
TranscriptomicsThe genome of Streptomyces rimosus shows a novel structure compared to other Streptomyces
This study compared the genome of Streptomyces rimosus rimosus against that of Streptomyces coelicolor. It also compared 4 strains with changes in oxytetracycline production and derived from G7, the type strain, against G7. Duplicate samples, each replicate may be found in the corresponding suppleme...
ORGANISM(S): Streptomyces rimosus 
2010-05-26 | E-GEOD-10126 | biostudies-arrayexpress
UnknownSRPX2 exhibits neuroprotective effects in neural stem cells: inhibition of OGD/R-stimulated apoptosis and oxidative stress.
Not available
S-EPMC12917582 | biostudies-literature
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