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TranscriptomicsChIP-chip of 6 chromatin marks (FAIRE, H3K4me1, H3K4me3, H3K27me3, H3R17me2, H3AZAce) in breast cancer cell line MCF7
Altered gene expression patterns in human diseases reflect perturbations in the transcriptional networks that regulate cellular state. In breast cancer, Nuclear Receptors (NRs) play a prominent role in governing gene expression. NRs have prognostic utility and are therapeutically important targets. ...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-42617 | biostudies-arrayexpress
TranscriptomicsGenome-wide Binding Site Mapping of Retinoic Acid Receptors and Coregulators in Breast Cancer Cells
Retinoic acid (RA) triggers growth-suppressive effects in tumor cells and therefore RA and its synthetic analogs have great potential as anti-carcinogenic agents. RA effects are mediated by retinoic acid receptors (RARs), which regulate gene expression in an RA-dependent manner. To define the geneti...
ORGANISM(S): Homo sapiens 
2009-03-16 | E-GEOD-15244 | biostudies-arrayexpress
TranscriptomicsA Chromatin Immunoprecipitation Approach Based on BAC Transgenesis
We have devised a technology that enables chromatin immunoprecipitation (ChIP) experiments in cultured human cells by circumventing both the laborious production of protein-specific antibodies and the optimization of crosslinking/immunoprecipitation conditions for each protein. Our approach utilizes...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-10845 | biostudies-arrayexpress
TranscriptomicsGenome-wide Binding Site Mapping of Estrogen Receptor alpha and c-MYC in Breast Cancer Cells
Estrogens are steroid hormones that play critical roles in the initiation, development, and metastasis of breast and uterine cancers. The estrogen (E2) response in breast cancer cells is predominantly mediated by the estrogen receptor-alpha (ER alpha), a ligand-activated transcription factor. ER a...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10800 | biostudies-arrayexpress
TranscriptomicsGene expression profiles in human kidney cancer cells in response to FoxO1 or FoxO3 activation
The mammalian FoxO transcription factors - FoxO1, FoxO3, FoxO4 - function in the nucleus to direct transcription of specific gene targets governing cellular survival, proliferation, metabolism, differentiation and oxidative defense. Activation of PI3K by extracellular growth factors leads to AKT-med...
ORGANISM(S): Homo sapiens 
2011-10-20 | E-GEOD-23926 | biostudies-arrayexpress
TranscriptomicsFtz and Eve ChIP data
Genome wide mapping of Ftz and Eve transcription factor binding sites in early Drosophila embryos Ftz has one replicate and dyes swapping Eve has two replicates with one dye swap Mock IPs were used as controls Slides were hybridized with two color samples, but individual channels were uploaded seper...
ORGANISM(S): Drosophila melanogaster 
2010-06-20 | E-GEOD-14289 | biostudies-arrayexpress
TranscriptomicsKras is required for pancreatic tumor maintenance through regulation of hexosamine biosynthesis and the non-oxidative pentose phosphate pathway
The maintenance of advanced malignancies relies on continued activity of driver oncogenes, although their rate-limiting role is highly context-dependent with respect to tumor types and associated genetic alterations. Oncogenic Kras mutation is the signature event in human pancreatic ductal adenocar...
ORGANISM(S): Mus musculus 
2012-04-29 | E-GEOD-32277 | biostudies-arrayexpress
TranscriptomicsDrosophila Ecdysone Receptor Study
We used the DamID method to systematically identify the binding sites of Ecdysone Receptor and its heterodimeric partner USP across the whole genome in Drosophila Kc cells. We find that the EcR sites are a subset of the USP sites and that only a proportion are ecdysone regulated from an accompanying...
ORGANISM(S): Drosophila melanogaster 
2008-05-01 | E-GEOD-9156 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of Lkb1 WT and KO hematopoietic stem cells (HSCs)
LKB1 encodes a Ser/Thr kinase and acts as an evolutionarily conserved sensor of cellular energy status in eukaryotic cells. LKB1 functions as the major upstream kinase to phosphorylate AMPK and 12 other AMPK-related kinases, which is required for their activation in many cellular contexts. Once acti...
ORGANISM(S): Mus musculus 
2010-12-01 | E-GEOD-24765 | biostudies-arrayexpress
TranscriptomicsEcdysone Response Timecourse in Kc Cells
Kc167 Cells were plated at 0.5x106/ml and grown at 23.50C. They were treated with 20-HE (Sigma) at a final concentration of 5x10-7M. The reference sample was total RNA isolated at 0 hr. after treatment. The experimental samples were total RNA isolated from cells treated for 1, 3, 6, 12, 24, and 48 h...
ORGANISM(S): Drosophila melanogaster 
2008-06-12 | E-GEOD-11625 | biostudies-arrayexpress
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