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GenomicsTo examine the role of p300 in the SMARCA4–p53 regulatory axis, we performed ChIP-seq to assess p300, p53, H3K27ac, HDAC1, HDAC2 occupancy in BIN-67 cells
ChIP-seq was performed in BIN-67, BIN-67 p53ko, BIN-67 with SMARCA4 restoration and BIN-67 p53ko cells with SMARCA4 restoration to assess the impact of SMARCA4 and p53 on the pull downs of p300, H3K27ac, p53, HDAC1 and HDAC2.
ORGANISM(S): Homo sapiens 
2026-05-05 | E-MTAB-15700 | biostudies-arrayexpress
GenomicsAssessing SMARCA4 restoration contribution to global changes in p300 occupancy in BIN-67 cells
We aim to test how SMARCA4 restoration impacts p300 occupancy distribution. To this aim we generated ChIP-seq samples in BIN-67 with or without A-485 treatment (1 μM, 24h), as a proxy for p300 acetylatransferase inhibition, and BIN-67 with inducible SMARCA4 restoration (1 μg/ml Doxycycline for 24h)....
ORGANISM(S): Homo sapiens 
2026-05-05 | E-MTAB-15699 | biostudies-arrayexpress
Transcriptomicsp53-ko rescues gene expression changes mediated by p300 acetyltransferase inhibition
RNA-seq samples in BIN-67 and BIN-67p53-ko cells with or without A-485 treatment (1μM, 24h). The goal of the experiment is to assess the genes that are regulated by p300 acetyltransferase inhibition using A-485 treatment and weather p53-ko can rescue this phenotype.
ORGANISM(S): Homo sapiens 
2026-05-05 | E-MTAB-15706 | biostudies-arrayexpress
TranscriptomicsExamining the effect of SMARCA4–p53 regulatory axis on SCCOHT cells transcription
To examine the role SMARCA4-p53 regulatory axis in SCCOHT cells we performed RNA-seq in BIN-67 cells with SMARCA4 restoration, p53ko alone or combined with SMARCA4 and idasanutlin treatment (0.5μM, 24h) which increase the stability of p53 and its protein levels in SCCOHT.
ORGANISM(S): Homo sapiens 
2026-05-05 | E-MTAB-15707 | biostudies-arrayexpress
TranscriptomicsEP300 acetyltransferase inhibition in SCCOHT cell lines
RNA-seq samples in BIN-67, COV434, SCCOHT-1 cells including Control (Ctrl.) and A-485 treatment (24h, 1μM)
ORGANISM(S): Homo sapiens 
2026-05-05 | E-MTAB-15705 | biostudies-arrayexpress
UnknownActivation of the STAT3 signaling pathway is associated with poor survival in diffuse large B-cell lymphoma treated with R-CHOP.
Not available
S-EPMC3871513 | biostudies-literature
ProteomicsDIA-Based Quantitative Proteomic Analysis of Early and Late Endosomes in A549 Cells Following Amphotericin B Pretreatment and Influenza A Virus Infection
Amphotericin B (AmB) is a polyene macrolide antifungal agent that binds to ergosterol, disrupting fungal membranes through lipid interactions. However, its effects on host cell protein composition remain unclear. In this study, A549 cells were pretreated with AmB prior to infection with the influenz...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD064637 | Pride
Amphotericin b  influenza a virus  endosome  dia proteomics 
TranscriptomicsLong term and short term Idasanutlin treatments in SCCOHT cell lines
RNA-seq samples in SCCOHT-1 and COV434 for idasanutlin treatment (0.5μM, 24h), and RNA-seq samples in BIN-67 and COV434 for short-term idasanutlin treatment (0.5μM, 3h). The goal of the experiment is to assess the genes that are regulated by p53 stabilization in the long term or short term using ida...
ORGANISM(S): Homo sapiens 
2026-05-05 | E-MTAB-16956 | biostudies-arrayexpress
ProteomicsPterosin B treatment protect cells from glutamate-induced cytotoxicity
The prevalence of neurodegenerative diseases is rapidly increasing with the aging trend of global populations, severely threatening human health and burdening society. However, to date, there is no effective treatment able to halt the progression or cure the diseases. Here, We aim to develop effecti...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-01 | PXD030396 | Pride
Ros Neuroprotective natural products Glutamate excitotoxicity Mitochondria membrane potential 
UnknownCCCH protein-PvCCCH69 acted as a repressor for leaf senescence through suppressing ABA-signaling pathway.
Not available
S-EPMC8263708 | biostudies-literature
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