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UnknownStructural Basis for pH-Dependent Oligomerization of Dihydropyrimidinase from Pseudomonas aeruginosa PAO1.
Dihydropyrimidinase, a dimetalloenzyme containing a carboxylated lysine within the active site, is a member of the cyclic amidohydrolase family, which also includes allantoinase, dihydroorotase, hydantoinase, and imidase. Unlike all known dihydropyrimidinases, which are tetrameric, pseudomonal dihyd...
S-EPMC5832032 | biostudies-literature
UnknownCombined effects of cigarette smoking, DNA methyltransferase 3B genetic polymorphism, and DNA damage on lung cancer.

Background

Smoking increases DNA methylation and DNA damage, and DNA damage acts as a vital cause of tumor development. The DNA methyltransferase 3B (DNMT3B) enhances promoter activity and methylation of tumor suppressor genes. Tea polyphenols may inhibit DNMT activity. We designed a case-co...
S-EPMC8480053 | biostudies-literature
UnknownD-methionine alleviates cisplatin-induced mucositis by restoring the gut microbiota structure and improving intestinal inflammation.

Background

There are close links between chemotherapy-induced intestinal mucositis and microbiota dysbiosis. Previous studies indicated that D-methionine was an excellent candidate for a chemopreventive agent. Here, we investigated the effects of D-methionine on cisplatin-induced mucositis.<...
S-EPMC6376546 | biostudies-literature
UnknownReal-Time Monitoring the Cytotoxic Effect of Andrographolide on Human Oral Epidermoid Carcinoma Cells.
Andrographolide is an active diterpenoid compound extracted from Andrographis paniculata. It exhibits antiinflammatory and anticancer effects. Previous studies show that it is non-toxic to experimental animals. The leading causes of cancer are chronic inflammation and high blood glucose. This...
S-EPMC9138648 | biostudies-literature
UnknownEctopic pregnancy, its potential links to dementia risk and interactions with depression: insights from a nationwide cohort study.

Background

Dementia poses a growing global mental health impact, with variations in prevalence by gender, possibly influenced by reproductive factors. Ectopic pregnancy (EP), known for its association with cardiovascular diseases and depression, which are also predictors of dementia, prompte...
S-EPMC11392761 | biostudies-literature
UnknownMale Infertility Increases the Risk of Cardiovascular Diseases: A Nationwide Population-Based Cohort Study in Taiwan.

Purpose

Some evidence suggests that male infertility increases the risk of cardiovascular diseases (CVDs). However, the evidence in Asian populations is relatively scarce. The aim of this study is to determine whether male infertility increases the risk of CVDs.

Materials and methods

...
S-EPMC9253797 | biostudies-literature
TranscriptomicsAge-related change of callus formation capability in Arabidopsis hypocotyls
Transcriptional profiling of age-related change of callus formation capability in Arabidopsis hypocotyls Organogenesis in vitro consists of many aspects such as phytohormone perception, dedifferentiation of differentiated cell to acquire organogenic competence, and re-entry of quiescent cells into c...
ORGANISM(S): Arabidopsis thaliana 
2011-06-19 | E-GEOD-27508 | biostudies-arrayexpress
UnknownAssociation of pelvic inflammatory disease (PID) with ectopic pregnancy and preterm labor in Taiwan: A nationwide population-based retrospective cohort study.

Background

Pelvic inflammatory disease (PID) is an infectious disease that causes tubal occlusion and other pelvic and abdominal adhesions. The incidence of pelvic inflammatory disease (PID) has increased due to the sexually active status of the young population. This leads to a more serious...
S-EPMC6692029 | biostudies-literature
UnknownObstructive sleep apnea increases risk of female infertility: A 14-year nationwide population-based study.

Objectives

To determine the risk of having OSA in a cohort of female subjects who are infertile and the odds of being infertile in women with OSA.

Patients and methods

A nationwide, case-control study of female patients 20 years or older diagnosed with female infertility living in Tai...
S-EPMC8673645 | biostudies-literature
UnknownImpact of glycemic treatment and blood glucose monitoring on outcomes in patients with acute ischemic stroke without prior diabetes: a longitudinal cohort study.

Objectives

To explore the short- and long-term effects of glycemic management-through glycemic treatment and blood glucose monitoring (BGM)-on stroke recurrence and mortality specifically in patients experiencing a first-ever ischemic stroke (FIS) with hyperglycemia (FISHG) who have not prev...
S-EPMC11657440 | biostudies-literature
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