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ProteomicsQuantitative proteomics analysis of acute myeloid leukemia cells after NAT10 knockdown
RNA modification represents an important post-transcriptional regulatory mechanism in acute myeloid leukemia (AML). Given that the critical function of ac4C in control RNA translation, we sought to investigate the global impact of ac4C on protein expression. To this end, we conducted tandem mass tag...
ORGANISM(S): Homo sapiens (Human) 
2024-08-26 | PXD055119 | Pride
Rna acetylation (ac4c)  acute myeloid leukemia  leukemic stem cells (lscs)  metabolic reprogramming  serine synthesis pathway  epigenetic inhibitor 
ProteomicsSpatiotemporal dog brain proteome
The complexity and low accessibility of the human brain make it challenging to understand its development, function, and disorders. Brain diseases including neurodegenerative disease and psychiatric diseases incur huge medical and social burdens without effective treatments. While mouse has substant...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2022-08-12 | PXD034449 | Pride
Brain Multiple regions Proteome Canine 
ProteomicsSpatiotemporal dog brain proteome
The complexity and low accessibility of the human brain make it challenging to understand its development, function, and disorders. Brain diseases including neurodegenerative disease and psychiatric diseases incur huge medical and social burdens without effective treatments. While mouse has substant...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2022-08-12 | PXD033420 | Pride
Brain Multiple regions Proteome Canine 
ProteomicsHAX1-interactome in Colorectal Cancer cell line (HCT116)
We performed immune-affinity purification and resolved the binding partners utilizing mass spectrometry to elucidate the molecular mechanism of HAX1-mediated CRC progression. HCT116 cells transfected with empty vector or Flag-HAX1 and then immunoprecipitated using anti-Flag M2 beads. The purified HA...
ORGANISM(S): Homo Sapiens 
2024-01-11 | PXD048485 |
ProteomicsMulberry leaf ameliorate STZ induced diabetic rat by regulating hepatic glycometabolism and fatty acid β-oxidation
Mulberry leaf ameliorate STZ induced diabetic rat by regulating hepatic glycometabolism and fatty acid β-oxidation
ORGANISM(S): Rattus Rattus 
2024-10-29 | PXD057279 |
TranscriptomicsALS-causative mutations in FUS/TLS confer gain- and loss-of-function by altered association with SMN and U1-snRNP
The RNA-binding protein FUS/TLS, mutation in which is causative of the fatal motor neuron disease ALS, is demonstrated to directly bind to the U1-snRNP and SMN complexes. ALS-causative mutations in FUS/TLS are shown to abnormally enhance their interaction with SMN and reduce interaction with U1-snRN...
ORGANISM(S): Homo sapiens 
2015-02-10 | E-GEOD-64078 | biostudies-arrayexpress
ProteomicsUSP14 Promotes Tryptophan Metabolism and Immune Suppression by Stabilizing IDO1 in Colorectal Cancer
IDO1 interacting proteins in two colorectal cancer cells and was subjected to beads, and the beads were washed by buffer and identified by mass spectrometry (MS)
ORGANISM(S): Homo Sapiens 
2022-05-05 | PXD033718 |
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