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MetabolomicsTubular insulin-induced gene 1 deficiency promotes NAD+ consumption and exacerbates kidney fibrosis

Profibrotic proximal tubular (PT) were identified as a unique phenotype of PTCs in renal fibrosis by single-cell RNA sequencing (scRNA-seq). Controlling the process of renal fibrosis requires understanding how to manage the S1 subset's branch to the S3 subset rather than to the profibrotic PT sub...

2024-05-28 | MTBLS9985 | MetaboLights
UnknownTET2 modulates spatial relocalization of heterochromatin in aged hematopoietic stem and progenitor cells.
Not available
S-EPMC11209854 | biostudies-literature
ProteomicsDisruption of ZC3H15 Compromises Telomere Length Maintenance by Sequestering Telomerase within Cajal bodies
Telomere homeostasis, crucial for various biological processes, relies on telomerase activity. We identified ZC3H15 as a novel telomerase-interacting protein. Its deletion unexpectedly increased telomerase activity but led to shortened telomeres and cellular senescence. ZC3H15 interacts with telomer...
ORGANISM(S): Homo Sapiens 
2024-05-06 | PXD052036 |
UnknownAberrant DNA hydroxymethylation reshapes transcription factor binding in myeloid neoplasms.
Not available
S-EPMC9241241 | biostudies-literature
Proteomicsproteomics analysis data from three different sCAFs and rCAFs
proteomics profiling analysis of three different chemo-sensitive and -resistant HNSCC patients derived CAFs.
ORGANISM(S): Homo Sapiens 
2022-11-23 | PXD038343 |
ProteomicsMechanistic view of NMNAT chaperoning different pathological proteins against amyloid aggregation
The cross-linking mass spectrometry raw data of NMNAT and amyloid client proteins including α-syn, K19, Aβ40, and IAPP.
ORGANISM(S): Homo Sapiens 
2022-02-11 | PXD031653 |
ProteomicsHippocampal proteomics analysis of marginal zinc deficiency
Zinc is an essential trace element that is closely related to learning and memory ability. The hippocampus plays an important role in learning and memory and has the highest zinc concentration in the brain. Severe zinc deficiency (zinc-deprived diet) significantly alter hippocampal protein expressio...
ORGANISM(S): Rattus Norvegicus 
2021-10-04 | PXD028998 |
ProteomicsComparative proteomics study of the WBCtrl and WBBMI1 cells
Comparative proteomics study of the WBCtrl and WBBMI1 cells
ORGANISM(S): Rattus Rattus 
2022-09-29 | PXD037074 |
ProteomicsSEPHS2 loss reprograms cancer metabolism from oxidative phosphorylation to gluconeogenesis via PCK1 stabilization
SEPHS2, a key enzyme in synthesizing selenoproteins, which converts hydrogen selenide into selenophosphate. Here we provide the proteome of SEPHS2 knockout human A375 celllines.
ORGANISM(S): Homo Sapiens 
2026-03-25 | PXD076137 |
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