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MetabolomicsMetabolomic assessment of acute cholestatic injuries induced by thioacetamide and by bile duct ligation, and the protective effects of Huang-Lian-Jie-Du-Decoction
Huang-Lian-Jie-Du-Decoction, a traditional Chinese formula, has been reported to protect liver from various injuries. Two cholestasis models of rats induced by thioacetamide and by bile duct ligation were established and treated with Huang-Lian-Jie-Du-Decoction. Nuclear Magnetic Resonance-based urin...
2016-06-08 | MTBLS149 | MetaboLights
MetabolomicsDifferential effects of Huang-Lian-Jie-Du Decoction on Alzheimer’s disease and normal rats

Introduction: Huang-Lian-Jie-Du Decoction (HLJDD), a botanical drug used in traditional medicine, has been used in the management of Alzheimer’s disease (AD). However, the mechanisms underlying its preventive effects remain inadequately understood, particularly due to the absence of metabolomic s...

2025-11-04 | MTBLS13256 | MetaboLights
ProteomicsS-nitrosoproteome of pancreatic ductal adenocarcinoma
NO performs its biological roles mainly through protein S-nitrosylation, but pathogenic roles of protein S-nitrosylation in PDAC remains largely unexplored. In this study, we identified large number of unique S-nitrosylation sites and proteins in PDAC patients and PANC-1 cells by a site-specific pro...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD012512 | Pride
Pancreatic ductal adenocarcinoma Panc-1 S-nitrosoproteome 
TranscriptomicsGene expression profiles of NIH3T3 cells stably transfected with the plasmids encoding the wild type PreS/S gene or the nonsense mutant gene (sW182*) of HBV.
Background and Aims: Whether hepatitis B virus (HBV) could play a direct role in hepatocarcinogenesis remains uncertain. The 3' end nonsense mutations of HBV PreS/S gene have been found to encode transcriptional transactivation activity, suggesting these mutations may contribute to HBV-associated on...
ORGANISM(S): Mus musculus 
2014-07-30 | E-GEOD-50180 | biostudies-arrayexpress
GenomicsSkeletonema costatum strain:Huang
Skeletonema costatum strain:Huang Transcriptome or Gene expression
PRJNA563119 | ENA
GenomicsSkeletonema costatum strain:Huang
Skeletonema costatum strain:Huang Transcriptome or Gene expression
PRJNA563118 | ENA
TranscriptomicsGenome plasticity in Streptomyces: identification of 1 Mb TIRs in the S. coelicolor A3(2) chromosome
The chromosomes of several widely used laboratory derivatives of Streptomyces coelicolor A3(2) were found to have 1.06 Mb inverted repeat sequences at their termini (i.e. long-terminal inverted repeats; L-TIRs), which are 50 times the length of the 22 kb TIRs of the sequenced S. coelicolor strain M1...
ORGANISM(S): Streptomyces coelicolor 
2005-07-26 | E-GEOD-2994 | biostudies-arrayexpress
TranscriptomicsS. coelicolor M145 Time-course Study in R5- medium (Culture# 3)
Antibiotic biosynthesis in Streptomyces species is controlled by a complex genetic and biochemical network of global and pathway specific regulators. Details of their precise interactions in mediating temporal and spatial expression of secondary metabolite genes remain poorly defined. In this stud...
ORGANISM(S): Streptomyces coelicolor 
2010-06-11 | E-GEOD-8107 | biostudies-arrayexpress
TranscriptomicsS. coelicolor Wild Type Time-course Study in R5- medium (Culture#1)
Antibiotic biosynthesis in Streptomyces species is controlled by a complex genetic and biochemical network of global and pathway specific regulators. Details of their precise interactions in mediating temporal and spatial expression of secondary metabolite genes remain poorly defined. In this stud...
ORGANISM(S): Streptomyces coelicolor 
2010-06-10 | E-GEOD-8084 | biostudies-arrayexpress
TranscriptomicsS. coelicolor Wild Type Time-course Study in R5- medium (Culture#2)
Antibiotic biosynthesis in Streptomyces species is controlled by a complex genetic and biochemical network of global and pathway specific regulators. Details of their precise interactions in mediating temporal and spatial expression of secondary metabolite genes remain poorly defined. In this stud...
ORGANISM(S): Streptomyces coelicolor 
2010-06-11 | E-GEOD-8086 | biostudies-arrayexpress
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