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Regulatory T cells (Treg) contribute to the crucial immunological processes of self-tolerance and immune homeostasis. However, the mechanisms underlying Treg function and cell fate decisions to differentiate between Treg and conventional T cells (Tconv) remain to be fully elucidated, especially at t...
ORGANISM(S): Homo sapiens 
PFKM is the second rate-limiting step of glycolysis, catalyzing the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate. Here we show, using an orthotopic xenograft glioma mouse model, that PFKM is deubiquitinated and translocated into nucleus upon glucose deficiency, thereby activa...
ORGANISM(S): Homo Sapiens 
2026-02-15 | PXD074827 |
CoronaVac (Sinovac), an inactivated vaccine for SARS-CoV-2, has been widely used for immunization. However, analysis of the underlying molecular mechanisms driving CoronaVac-induced immunity is still limited. Here, we applied a systems biology approach to understand the mechanisms behind the adaptiv...
ORGANISM(S): Homo Sapiens 
2022-03-09 | PXD032127 |
Despite efforts made to reveal the underlying cause for differences in host responses and severity to Rrespiratory syncytial virus (RSV) infectionis an important pathogen causing pneumonia in children, few studies have used multi-omics data to investigate the pathogenies of RSV pneumonia. Here, meta...
ORGANISM(S): Homo Sapiens 
2023-02-14 | PXD040110 |
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