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TranscriptomicsCombined inhibition of TGFM-NM-2 and PDGF signaling attenuates radiation-induced pulmonary fibrosis
To investigate effects on mRNA expression in mouse lung tissue through treatment with Ly, Su, Imatinib, irradiation and combinations of them. mRNA expression was measured 24 days after irradiation. 2 biological replicates were analyzed for each treatment condition (control, Ly, Imatinib, Su, Ly+Imat...
ORGANISM(S): Mus musculus 
2015-01-15 | E-GEOD-65011 | biostudies-arrayexpress
TranscriptomicsMolecular classification of mature aggressive B cell lymphoma using digital multiplexed gene expression on formalin-fixed paraffin-embedded biopsy specimens [Affymetrix]
The most frequent mature aggressive B-cell lymphomas are diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL). Patients suffering from molecularly defined BL (mBL) but treated with a regimen developed for DLBCL show an unfavorable outcome compared to mBL treated with chemotherapy regimens...
ORGANISM(S): Homo sapiens 
2013-09-25 | E-GEOD-48097 | biostudies-arrayexpress
ProteomicsIn situ analysis of osmolyte mechanisms of proteome thermal stabilisation
Organisms across all kingdoms of life use small organic molecules called osmolytes to adapt to diverse environmental conditions and preserve viability. Osmolytes are thought to thermally stabilise proteins based on in vitro studies of a few purified proteins. The molecular mechanisms of osmolytes re...
ORGANISM(S): Escherichia coli 
2024-08-09 | PXD036186 | Pride
Osmolyte mechanisms Structural proteomics Stress adaptation Thermal stabilisation Aggregation 
TranscriptomicsAnalyzing synergistic and non-synergistic interactions in signalling pathways using Boolean Nested Effect Models
Understanding the structure and interplay of cellular signalling pathways is one of the great challenges in molecular biology. Boolean Networks can infer signalling networks from observations of protein activation. In situations where it is difficult to assess protein activation directly, Nested Eff...
ORGANISM(S): Homo sapiens 
2015-12-10 | E-GEOD-68761 | biostudies-arrayexpress
TranscriptomicsBiologic characterization of adult MYC-positive mature B-cell lymphomas other than molecular Burkitt lymphoma
MYC translocations are the biologic hallmark of Burkitt lymphomas but also occur in other mature B-cell lymphomas. If accompanied by chromosomal breaks targeting the BCL2 and/or BCL6 oncogenes, these MYC translocation-positive (MYC+) lymphomas are called double-hit lymphomas (DHLs); otherwise, the t...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-44164 | biostudies-arrayexpress
TranscriptomicsTranslocations Activating IRF4 Identify a Subtype of Germinal-Center-Derived B-cell Lymphoma Affecting Predominantly Children and Young Adults
Background: Germinal center B-cell (GCB) lymphomas are common in children and adults. The prognosis strongly depends on age. Subgroups of GCB-lymphomas are characterized by chromosomal translocations affecting immunoglobulin (IG) loci leading to oncogene deregulation. Methods: Novel IG translocation...
ORGANISM(S): Homo sapiens 
2011-06-24 | E-GEOD-22470 | biostudies-arrayexpress
ProteomicsThe Nα-acetyltransferase NAA50 mediates plant immunity independent of the NatA complex
Nα-terminal acetylation (NTA) ranges among the most abundant protein modifications in higher eukaryotes. Over 40 % of the human and plant proteome are co-translationally acetylated by a single Nα-acetyltransferase (Nat) termed NatA. The core NatA complex consists of the catalytic subunit NAA10 and t...
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress) 
2024-03-01 | PXD040755 | JPOST Repository
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