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UnknownClofarabine plus cytarabine compared with cytarabine alone in older patients with relapsed or refractory acute myelogenous leukemia: results from the CLASSIC I Trial.
Not available
S-EPMC4874149 | biostudies-literature
GenomicsGenome wide binding sites of NF-κB subunits RelA, RelB, p50, and p52 in the Hodgkin lymphoma cell line L1236
The malignant cells of Hodgkin's lymphoma are characterized by a constitutive activation of the canonical as well as the non-canonical NF-κB signaling cascades. We carried out genome-wide localization and expression profiling experiments in the Hodgkin lymphoma cell line L1236 for the canonical and...
ORGANISM(S): Homo sapiens 
2016-02-18 | E-GEOD-63736 | biostudies-arrayexpress
TranscriptomicsA combined RNAi and localization approach for dissecting long noncoding RNAs reveals a function of Panct1 in ES cells
Long non-coding RNAs (lncRNAs) regulate diverse biological pathways. Unlike protein coding genes, where methods to comprehensibly study their functional roles in cellular systems are available, techniques to systematically investigate lncRNAs have largely remained unexplored. Here, we report a techn...
ORGANISM(S): Mus musculus 
2012-02-15 | E-GEOD-29798 | biostudies-arrayexpress
GenomicsHigh salt reduces the activation of IL-4+IL-13 stimulated macrophages
High salt (NaCl) intake is a major risk factor for cardiovascular disease; high NaCl has also been shown to be a powerful modulator of pro-inflammatory immune cell polarization. To investigate the effect of high NaCl on the polarization of M(IL-4+IL-13) macrophages we performed gene expression analy...
ORGANISM(S): Mus musculus 
2015-02-07 | E-MTAB-3140 | biostudies-arrayexpress
ProteomicsEnabling phenotypic drug discovery for neurological mitochondrial DNA disorders with patient-derived neural progenitor cells
Mitochondrial DNA (mtDNA) mutations predominantly cause neurological diseases. Searching for therapeutic strategies is hindered by the absence of viable neural model systems due to the challenges of engineering mtDNA. We demonstrate that neural progenitor cells (NPCs), rapidly obtained from human in...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080849 | MassIVE
TranscriptomicsComparative Transcriptional Profiling of the Axolotl Limb Identifies a Tripartite Regeneration-Specific Gene Program
Identifying the genetic program that induces limb regeneration in salamanders is an important resource for regenerative medicine, which currently lacks tools to promote regeneration of functional body structures. The genetic network underlying limb regeneration has been elusive due to the complexit...
ORGANISM(S): Ambystoma mexicanum 
2013-01-01 | E-GEOD-36451 | biostudies-arrayexpress
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