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TranscriptomicsStrategies for in vivo screening and mitigation of hepatotoxicity associated with antisense drugs
In this study we tested and modeled the hepatotoxic potential of locked nucleic acid-containing phosphorothioated antisense oligonucleotide (ASOs) gapmers designed to target human BACH1 and PAR-2 transcripts. Using RNA extracted from mouse livers we compared expression profiles of off-target (i.e. g...
ORGANISM(S): Mus musculus 
2017-08-02 | E-MTAB-5180 | biostudies-arrayexpress
TranscriptomicsThe Folliculin-Fnip1 pathway deleted in human Birt-Hogg-Dube syndrome is required for B cell development.
Birt-Hogg-Dube (BHD) syndrome is an autosomal dominant disorder characterized by hamartomas of skin follicles, cystic lung disease, and renal neoplasia. Affected individuals carry heterozygous mutations in Folliculin (FLCN), a tumor suppressor gene that becomes biallelically inactivated in kidney t...
ORGANISM(S): Mus musculus 
2012-06-16 | E-GEOD-38741 | biostudies-arrayexpress
ProteomicsLKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers
KRAS-mutant lung cancers frequently have inactivating mutations in LKB1, which enhances tumor growth, metastasis, and immune evasion. This study shows that LKB1 suppresses JNK stress signaling, and its loss in KRAS-mutant cells leads to JNK hyperactivation and apoptotic rewiring, making them sensiti...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-03-06 | MSV000097246 | MassIVE
UnknownDefining the volume of consultations for musculoskeletal infection encountered by pediatric orthopaedic services in the United States.
Not available
S-EPMC7272072 | biostudies-literature
UnknownX-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19.
Not available
S-EPMC8532080 | biostudies-literature
UnknownRare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19.
Not available
S-EPMC10074346 | biostudies-literature
UnknownThe major genetic determinants of HIV-1 control affect HLA class I peptide presentation.
Not available
S-EPMC3235490 | biostudies-literature
UnknownThe Association of Baseline Plasma SARS-CoV-2 Nucleocapsid Antigen Level and Outcomes in Patients Hospitalized With COVID-19.
Not available
S-EPMC9447373 | biostudies-literature
UnknownViral and Host Factors Are Associated With Mortality in Hospitalized Patients With COVID-19.
Not available
S-EPMC11175705 | biostudies-literature
UnknownMeta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years.
Not available
S-EPMC5299468 | biostudies-literature
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