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TranscriptomicsAspirin Exposure Reveals Novel Genes Associated with Platelet Function and Cardiovascular Events (outpatient cardiology)
Background: Identifying individuals at heightened cardiovascular risk is a priority for reducing the global burden of cardiovascular disease. Aspirin is widely used to prevent cardiovascular events, though with variable results. Therefore, we hypothesized that aspirin exposure would reveal novel b...
ORGANISM(S): Homo sapiens 
2013-12-06 | E-GEOD-38511 | biostudies-arrayexpress
no omics definedTiling path analysis of seven temperature sensitive S. cerevisiae BY4741 mutants
Seven temperature sensitive Saccharomyces cerevisiae BY4741 mutants (rsc3-1, abf1-101, reb1-212, rap1-1, mcm1, tbf1 and cep3-1) were grown at restrictive temperatures until a difference in OD600 was observed relative to a wild-type control. Nucleosomal DNA, whole genomic DNA and total RNA were isola...
ORGANISM(S): Saccharomyces cerevisiae 
2009-01-15 | E-MEXP-1754 | biostudies-arrayexpress
TranscriptomicsPrediction and Testing of Novel Transcriptional Networks Regulating Embryonic Stem Cell Self-Renewal and Commitment
We have used mouse embryonic stem cells (ESCs) as a model to study the signaling mechanisms that regulate self-renewal and commitment to differentiation. We hypothesized that genes critical to stem cell fate would be dynamically regulated at the initiation of commitment. Time course microarray analy...
ORGANISM(S): Mus musculus 
2010-06-11 | E-GEOD-7520 | biostudies-arrayexpress
ProteomicsHydrogen deuterium exchange epitope mapping of glycosylated epitopes enabled by online immobilized glycosidase
Numerous mAbs are known to recognize N-glycosylated epitopes or to bind in close proximity to an N-glycan site, however, glycosylated protein sites are typically obscured from HDX detection as a result of the inherent heterogeneity of glycans. To overcome this limitation, we covalently immobilized ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD041204 | Pride
Lc/ms-ms Hdx 
TranscriptomicsA compendium of nucleosome and transcript profiles reveals determinants of chromatin architecture and transcription [nucleosome profiling]
Nucleosomes in all eukaryotes examined to date adopt a characteristic architecture within genes and play fundamental roles in regulating transcription, yet the identity and precise roles of many of the trans-acting factors responsible for the establishment and maintenance of this organization remain...
ORGANISM(S): Saccharomyces cerevisiae 
2013-05-22 | E-GEOD-44877 | biostudies-arrayexpress
TranscriptomicsA compendium of nucleosome and transcript profiles reveals determinants of chromatin architecture and transcription
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Saccharomyces cerevisiae 
2013-05-22 | E-GEOD-44879 | biostudies-arrayexpress
TranscriptomicsA compendium of nucleosome and transcript profiles reveals determinants of chromatin architecture and transcription [transcript profiling]
Nucleosomes in all eukaryotes examined to date adopt a characteristic architecture within genes and play fundamental roles in regulating transcription, yet the identity and precise roles of many of the trans-acting factors responsible for the establishment and maintenance of this organization remain...
ORGANISM(S): Saccharomyces cerevisiae 
2013-05-22 | E-GEOD-44876 | biostudies-arrayexpress
TranscriptomicsRNAcompete: a method for rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins
Metazoan genomes encode hundreds of RNA binding proteins (RBPs) but relatively few have well-defined RNA-binding preferences. Current techniques for determining RNA targets, including those involving in vitro selection and RNA co-immunoprecipitation, require significant time and labour investment. H...
ORGANISM(S): synthetic construct 
2010-05-18 | E-GEOD-15769 | biostudies-arrayexpress
TranscriptomicsMouse Exons
Exon tiling array encompassing 837,251 probes across the mouse genome. 12 tissue pools. Composition of the 12 mRNA pools analyzed (mRNA per array hybridization): 1- Heart (2 microgram), Skeletal muscle (2 microgram) 2- Liver (2 microgram) 3- Whole brain (1.5 microgram), Cerebellum (0.48 micr...
ORGANISM(S): Mus musculus 
2010-07-01 | E-GEOD-3047 | biostudies-arrayexpress
TranscriptomicsSMAUG Is a Major Regulator of Maternal mRNA Destabilization in Drosophila
In animals, egg activation triggers a cascade of posttranscriptional events that act on maternally synthesized RNAs. We show that, in Drosophila, the PAN GU (PNG) kinase sits near the top of this cascade, triggering translation of SMAUG (SMG), a multifunctional posttranscriptional regulator conserve...
ORGANISM(S): Drosophila melanogaster 
2007-09-13 | E-GEOD-8910 | biostudies-arrayexpress
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