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TranscriptomicsGene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity (Exiqon)
Adipose tissue abundance relies partly on the factors that regulate adipogenesis, i.e. proliferation and differentiation of adipocytes. While the transcriptional program that initiates adipogenesis is well-known, the importance of microRNAs in adipogenesis is less well studied. We thus set out to in...
ORGANISM(S): Mus musculus 
2011-05-31 | E-GEOD-27912 | biostudies-arrayexpress
TranscriptomicsGW7647 and Rosiglitazone treated human differentiated adipocytes
Objective : This work aimed at characterizing PPARα involvement in metabolism regulation and at comparing PPARα and PPARγ roles in human white adipocytes. Research Design and Methods : Profiling of gene expression alterations was assessed with microarrays and RT-qPCR. Primary cultures of human adipo...
ORGANISM(S): Homo sapiens 
2010-04-11 | E-GEOD-15862 | biostudies-arrayexpress
TranscriptomicsMicroarray Analysis of Genes Regulated by Macrophage-Conditioned Media Treatment of Human Pre-Adipocytes
A major development in the study of obesity is the recognition that the condition is characterised by chronic mild inflammation. Within adipose tissue, this involves the infiltration of macrophages, as well as the direct inflammatory response of the adipocytes and pre-adipocytes. This study has us...
ORGANISM(S): Homo sapiens 
2011-12-21 | E-GEOD-27503 | biostudies-arrayexpress
TranscriptomicsGene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity
This SuperSeries is composed of the following subset Series: GSE27912: Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity (Exiqon) GSE27949: Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity (Affymetri...
ORGANISM(S): Homo sapiens 
2011-06-10 | E-GEOD-27951 | biostudies-arrayexpress
TranscriptomicsHypoxia-induced modulation of gene expression in human adipocytes - A microarray study
Obesity is characterised by expansion of white adipose tissue, accompanied by an inflamatory response. It has been proposed that the inflammatory state observed may be linked to relative hypoxia in clusters of adipocytes distant from vasculature. Adipose tissue hypoxia has been observed in both an...
ORGANISM(S): Homo sapiens 
2012-03-09 | E-GEOD-34007 | biostudies-arrayexpress
TranscriptomicsEffects of bisphenol A on gene expression in adipocytes from lean children: association to metabolic disorders
Bisphenol A (BPA) is a xenobiotic endocrine disrupting chemical. In vitro and in vivo studies indicated that BPA alters endocrine-metabolic pathways in adipose tissue increasing the risk of developing metabolic disorders. BPA effects on human adipocytes, specifically in children, are poorly investig...
ORGANISM(S): Homo sapiens 
2015-07-09 | E-GEOD-58516 | biostudies-arrayexpress
GenomicsTransient SUMOylation Inhibition In Human Pre-adipocytes Stably Imprints a Transcriptional Beiging Fate
Transient SUMOylation Inhibition In Human Pre-adipocytes Stably Imprints a Transcriptional Beiging Fate
PRJNA1378966 | ENA
TranscriptomicsExpression data from differentiated 3T3-L1 pre-adipocytes.
Stearoyl-CoA desaturase (SCD) is the rate-limiting enzyme catalyzing the conversion of saturated fatty acids palmitate and stearate to monounsaturated fatty acids palmitoleate and oleate. During adipocyte differentiation, SCD expression increases concomitantly with several transcription factors and ...
ORGANISM(S): Mus musculus 
2014-04-04 | E-GEOD-51905 | biostudies-arrayexpress
TranscriptomicsExpression data from human subcutaneous adipocytes
An Affimetrix GeneChip Human Genome U133 Plus 2.0 Array was used to study the effect of oleoylethnolamide on gene expression. The addition of 0.01 mM oleoylethanolamide (OEA) to human subcutaneous adipocytes significantly affected the expression of 1013 genes, with 556 being up-regulated and 457 bei...
ORGANISM(S): Homo sapiens 
2014-11-04 | E-GEOD-55539 | biostudies-arrayexpress
TranscriptomicsGene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity (Affymetrix)
Adipose tissue abundance relies partly on the factors that regulate adipogenesis, i.e. proliferation and differentiation of adipocytes. While the transcriptional program that initiates adipogenesis is well-known, the importance of microRNAs in adipogenesis is less well studied. We thus set out to in...
ORGANISM(S): Homo sapiens 
2011-05-31 | E-GEOD-27949 | biostudies-arrayexpress
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