Sort   by:  
 Page size 
MetabolomicsBMAL1-depletion remodels ceramide metabolism to regulate ferroptosis and sorafenib chemosensitivity in acute myeloid leukemia
Acute myeloid leukemia (AML) is a hematologic malignancy with a poor prognosis. We discovered that BMAL1 is a ferroptosis suppressor. Furthermore, it was also found to be overexpressed in AML patients, affecting the cell cycle and promoting tumor cell growth and progression. In this study, we furthe...
2025-01-24 | MTBLS11557 | MetaboLights
MetabolomicsParallel single-cell metabolic analysis and extracellular vesicle profiling reveal vulnerabilities with prognostic significance in acute myeloid leukemia (Lipidomic analysis on extracellular vesicles)

Acute myeloid leukemia (AML) is an aggressive disease with a high relapse rate. In this study, we map the metabolic profile of CD34+(CD38low/-) AML cells and the extracellular vesicle signatures in circulation from AML patients at diagnosis. CD34+ AML cells display high antioxidant glutathione le...

2024-12-04 | MTBLS11523 | MetaboLights
MetabolomicsParallel single-cell metabolic analysis and extracellular vesicle profiling reveal vulnerabilities with prognostic significance in acute myeloid leukemia (Metabolomic analysis on extracellular vesicles)

Acute myeloid leukemia (AML) is an aggressive disease with a high relapse rate. In this study, we map the metabolic profile of CD34+(CD38low/-) AML cells and the extracellular vesicle signatures in circulation from AML patients at diagnosis. CD34+ AML cells display high antioxidant glutathione le...

2024-12-04 | MTBLS11746 | MetaboLights
TranscriptomicsIntegrative nucleophosmin mutation-associated microRNA and gene expression pattern analysis identifies novel microRNA - target gene interactions in acute myeloid leukemia
Background: MicroRNAs are regulators of gene expression, mainly functioning by decreasing mRNA levels of their multiple targets. Deregulated microRNA expression has been shown for acute myeloid leukemia, a disease also characterized by altered gene expression associated with distinct genomic aberrat...
ORGANISM(S): Homo sapiens 
2011-09-11 | E-GEOD-31644 | biostudies-arrayexpress
TranscriptomicsMusashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia
RNA-binding proteins of the Musashi (Msi) family are expressed in stem cell compartments and in aggressive tumors, but they have not yet been widely explored in the blood. Here we demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSCs), and its knockdown leads to r...
ORGANISM(S): Homo sapiens 
2010-07-11 | E-GEOD-16432 | biostudies-arrayexpress
GenomicsWhole exome sequencing analyses of human, IDH2-mutated, acute myeloid leukemia samples from patients before or during treatment with Enasidenib.
Mutations in isocitrate dehydrogenase 2 (IDH2) occur in many cancers including Acute Myeloid Leukemia (AML). In preclinical models mutant IDH2 causes partial hemopoietic differentiation arrest. Recently, we showed that single agent Enasidenib, a first-in-class, selective mutant IDH2 inhibitor, produ...
ORGANISM(S): Homo sapiens 
2018-08-13 | E-MTAB-6299 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing of erythroid and megakaryocytic acute myeloid leukemia patient cells
Single-cell RNA sequencing was performed on bone marrow mononuclear of a patient with acute myeloid leukemia with erythroid differentiation of the blasts and on peripheral blood mononuclear cells of a patient with acute myeloid leukemia with megakaryocytic differentiation of the blasts. Raw data for...
ORGANISM(S): Homo sapiens 
2022-12-05 | E-MTAB-12607 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human samples of bone morrow or peripheral blood mononuclear cells from adult patients with untreated acute myeloid leukemia to develop a prognostic gene signature for normal karyotype AML
Patients with cytogenetically normal acute myeloid leukemia (CN-AML) show heterogeneous treatment outcomes. We used gene expression profiling to develop a gene signature that predicts overall survival (OS) in CN-AML. Based on data from 163 patients treated in the German AMLCG 1999 trial and analyzed...
ORGANISM(S): Homo sapiens 
2008-10-26 | E-GEOD-12417 | biostudies-arrayexpress
GenomicsIntegrative epigenomic analysis in MLL-AF9 acute myeloid leukemia (AML) and B-acute lymphoblastic leukemia (B-ALL)
Next generation DNA sequencing of acute myeloid leukemia (AML) patient samples has revealed novel recurrent mutations while at the same time highlighting the genetic heterogeneity of the disease. These observations suggest that an extraordinarily large number of combinations of mutations can contrib...
ORGANISM(S): Homo sapiens 
2017-05-02 | E-GEOD-70755 | biostudies-arrayexpress
TranscriptomicsSingle cell long read genotyping of transcripts reveals discrete mechanisms of clonal evolution in post-MPN AML
Myeloproliferative neoplasm (MPN) or post-MPN acute myeloid leukemia patient bone marrow aspirates were sorted for CD34+ hematopoietic stem and progenitor cells (HSPCs), followed by 10x 3' single cell RNA sequencing and long read sequencing to study the consequences of mutation combination on HSPCs.
ORGANISM(S): Homo sapiens 
2026-06-25 | E-MTAB-15981 | biostudies-arrayexpress
Sort   by:  
 Page size