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MetabolomicsIon mobility-based sterolomics reveals spatially and temporally distinctive sterol lipids in the mouse brain
Aberrant sterol lipid metabolism is associated with physiological dysfunctions in the aging brain and aging-dependent disorders such as neurodegenerative diseases. There is an unmet demand to comprehensively profile sterol lipids spatially and temporally in different brain regions during aging. Here...
2021-05-24 | MTBLS2457 | MetaboLights
MetabolomicsAbsolute quantitative lipidomics reveals lipidome-wide alterations in aging brain (Mouse brain NEG UPLC-MS assay)

INTRODUCTION: The absolute quantitation of lipids at the lipidome-wide scale is a challenge but plays an important role in the comprehensive study of lipid metabolism.

OBJECTIVES: We aim to develop a high-throughput quantitative lipidomics approach to enab...

2018-08-03 | MTBLS495 | MetaboLights
MetabolomicsBiochemical Profiling of the Brain and Blood Metabolome in a Mouse Model of Prodromal Parkinson’s Disease Reveals Distinct Metabolic Profiles (NMR assay)
Parkinson’s disease is the second most common neurodegenerative disease. In the vast majority of cases the origin is not genetic and the cause is not well understood, although progressive accumulation of α-synuclein aggregates appears central to the pathogenesis. Currently, treatments that slow dise...
2019-02-07 | MTBLS640 | MetaboLights
MetabolomicsBiochemical Profiling of the Brain and Blood Metabolome in a Mouse Model of Prodromal Parkinson’s Disease Reveals Distinct Metabolic Profiles (MS assays)
Parkinson’s disease is the second most common neurodegenerative disease. In the vast majority of cases the origin is not genetic and the cause is not well understood, although progressive accumulation of α-synuclein aggregates appears central to the pathogenesis. Currently, treatments that slow dise...
2019-02-07 | MTBLS674 | MetaboLights
MetabolomicsAbsolute quantitative lipidomics reveals lipidome-wide alterations in aging brain (Mouse brain POS UPLC-MS assay)

INTRODUCTION: The absolute quantitation of lipids at the lipidome-wide scale is a challenge but plays an important role in the comprehensive study of lipid metabolism.

OBJECTIVES: We aim to develop a high-throughput quantitative lipidomics approach to enab...

2018-08-03 | MTBLS562 | MetaboLights
MetabolomicsDisruption of the Brain-Spleen Axis Impairs Monocyte-Microglia Communication and Accelerates Disease Progression in a Mouse Model of Amyloidosis
Alzheimer’s disease (AD) is characterized by a prolonged asymptomatic phase before cognitive decline emerges, yet the mechanisms driving symptom onset remain unclear. Here, we hypothesized that the transition from asymptomatic to symptomatic disease is linked to dysfunction of brain–immune communica...
2026-06-01 | MTBLS14615 | MetaboLights
MetabolomicsGut microbiota-derived butyric acid protected against secondary brain injury after SAH by inhibiting neuronal pyroptosis and regulating gut microbiota composition (Human assays)

BACKGROUND: Subarachnoid hemorrhage (SAH) is a devastating cerebrovascular disease with a poor prognosis. Accumulating studies have reported that gut microbiota contributes to the pathophysiology of several central nervous system diseases. However, whether SAH can change gut micr...

2024-07-09 | MTBLS9087 | MetaboLights
MetabolomicsElevated brain manganese induces motor disease by upregulating the kynurenine pathway of tryptophan metabolism
Elevated brain levels of the essential metals manganese (Mn), copper, or iron induce motor disease. However, mechanisms of metal-induced motor disease are unclear and treatments are lacking. Elucidating the mechanisms of Mn-induced motor disease is particularly important because occupational and env...
2025-03-31 | MTBLS975 | MetaboLights
MetabolomicsMicrobiota-derived p-cresol and indole metabolites mediates neurotoxic gut-brain axis dysregulation in ALS
Integrated metabolomic profiling demonstrated a marked increase in microbiota-derived metabolites, particularly along aromatic amino acid pathways. Notably, p-cresol metabolites were significantly elevated in both brain and circulation, suggesting enhanced microbial phenylalanine/tyrosine metabolism...
2026-08-21 | MTBLS14404 | MetaboLights
MetabolomicsMulti-Omics Analysis Reveals Alcohol exposure affects Ferroptosis pathway in Brain

Alcohol-related brain damage (ARBD) constitutes a major global public health issue and is often comorbid with neuropsychiatric disorders such as Alzheimer's and Parkinson's diseases. Ferroptosis, a form of regulated cell death characterized by iron dependency and lipid peroxidation, has been impl...

2026-03-11 | MTBLS14025 | MetaboLights
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