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UnknownDissecting the effect of mitochondrial BCAT inhibition in methylmalonic acidemia.
Not available
S-EPMC12487681 | biostudies-literature
UnknownThe Critical Role of the Branched Chain Amino Acids (BCAAs) Catabolism-Regulating Enzymes, Branched-Chain Aminotransferase (BCAT) and Branched-Chain α-Keto Acid Dehydrogenase (BCKD), in Human Pathophysiology.
Not available
S-EPMC8999875 | biostudies-literature
TranscriptomicsAB001
Diamond-Blackfan anemia (DBA) is a congenital disorder that results predominantly from mutations in various ribosomal protein genes. In order to determine how these mutations affect the translation of specific mRNAs, we performed microarray analysis of polysomal transcripts isolated from lymphoblast...
ORGANISM(S): Homo sapiens 
2014-01-30 | E-GEOD-43117 | biostudies-arrayexpress
ProteomicsEnhanced Branched-Chain Amino Acid Metabolism Improves 7 Age-Related Reproduction
Reproductive aging is one of the earliest human aging phenotypes, and mitochondrial dysfunction has been linked to a decline in oocyte quality. However, it is not known which mitochondrial metabolic processes are critical for oocyte quality maintenance with age. To understand how mitochondrial proce...
ORGANISM(S): Caenorhabditis elegans 
2024-01-15 | PXD048296 | Pride
Reproductive Mytochondria Proteomics Aging 
UnknownBCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases.
Not available
S-EPMC5510229 | biostudies-literature
UnknownDecreased expression of the mitochondrial BCAT protein correlates with improved patient survival in IDH-WT gliomas.
Not available
S-EPMC8029096 | biostudies-literature
UnknownThe mechanism of branched-chain amino acid transferases in different diseases: Research progress and future prospects.
Not available
S-EPMC9478667 | biostudies-literature
TranscriptomicsBeta-catenin Controls Metastasis in Braf-activated Pten-inactivated Melanomas
Malignant melanoma is characterized by frequent metastasis, however specific changes that regulate this process have not been clearly delineated. Although it is well known that Wnt signaling is frequently dysregulated in melanoma, the functional implications of this observation are unclear. By modul...
ORGANISM(S): Mus musculus 
2011-10-12 | E-GEOD-32907 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of the transcriptomes of mouse embryonic stem cells (mESC) maintained in different indicated conditions.
Analysis of genes involved in the mESC maintainance between different conditions of growth. The hypothesis tested in the present study was that Myc can sustain mESC self renewal and pluripotency. Results provide important information on the mechanism by which Myc supports mESC self renewal, in compa...
ORGANISM(S): Mus musculus 
2016-03-31 | E-GEOD-58656 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of human marcrophages treated with lipopolysaccharide (LPS) for 8 hours, with or without BCAT1 inhibitor (ERG240)
Branched-chain aminotransferases (BCAT) are enzymes that initiate the catabolism of branched-chain amino acids (BCAA), such as leucine, thereby providing macromolecule precursors. In order to study the effect of BCAT1 inhibitor (ERG240) on LPS-polarized macrophage transcriptome, we stimulated monocy...
ORGANISM(S): Homo sapiens 
2020-11-23 | GSE148701 | GEO
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