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MetabolomicsMetabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites (Cohort 1)

Despite improvement in clinical management, allogeneic hematopoietic stem cell transplantation (HSCT) is still hampered by high morbidity and mortality rates, mainly due to Graft versus host disease (GvHD). Recently, it has been demonstrated that the allogeneic immune response might be influenced...

2019-11-06 | MTBLS204 | MetaboLights
MetabolomicsMetabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites (Cohort 2)

Despite improvement in clinical management, allogeneic hematopoietic stem cell transplantation (HSCT) is still hampered by high morbidity and mortality rates, mainly due to Graft versus host disease (GvHD). Recently, it has been demonstrated that the allogeneic immune response might be influenced...

2019-11-06 | MTBLS205 | MetaboLights
MetabolomicsAnalysis of the human adult urinary metabolome variations with age, body mass index and gender by implementing a comprehensive workflow for univariate and OPLS statistical analyses. ('Sacurine' data set)

Urine metabolomics is widely used for biomarker research in the fields of medicine and toxicology. As a consequence, characterization of the variations of the urine metabolome under basal conditions becomes critical in order to avoid confounding effects in cohort studies. Such physiological infor...

2017-01-20 | MTBLS404 | MetaboLights
MetabolomicsDigital Phenomics and Dual-Fluid Metabolomics for Precision Stratification of Diabetic Kidney Disease: A Multicenter Cohort Study

We conducted a prospective-retrospective two-center cohort study involving 364 participants. The Discovery Cohort (n=282) enrolled from two centers consisted of healthy controls (n=80), patients with type 2 diabetes mellitus (T2DM) without kidney disease (n=102), and patients with confirmed DKD (...

2026-03-09 | MTBLS14007 | MetaboLights
MetabolomicsDiagnostic utility of clinicodemographic, biochemical and metabolite variables to identify viable pregnancies in a symptomatic cohort during early gestation.

Study question: Can a novel machine learning pipeline create predictive models that identify a composite biomarker to differentiate live normally sited pregnancies (LNSP) from non-viable pregnancies in women presenting with pain and/or bleeding in early gestation?

Summary answer: Serum met...

2025-08-14 | MTBLS6219 | MetaboLights
MetabolomicsDecipher aging related skin microbiome and metabolites crosstalk from a chronologically matched cohort

Aging has shown close link to shifts in the skin microbiome in population cohort study. However, how variations in microbial communities relate to divergent skin aging within individuals of the same chronological ages remains unclear. In this study, we performed phenotypic, metabolomic and metage...

2025-01-03 | MTBLS11994 | MetaboLights
MetabolomicsUHPLC-OE-MS metabolic profile of follicular fluid in patients with ovarian endometriosis: a pilot study of an endometriosis cohort

BACKGROUND: Endometriosis is a common benign gynaecological disorder. A number of studies have confirmed that the occurrence of disease in endometriosis patients is associated with metabolic changes in biological fluids and tissues. We set out to investigate the metabolic charact...

2024-02-20 | MTBLS8621 | MetaboLights
MetabolomicsLC−MS Based Serum Metabolomics for Identification of Hepatocellular Carcinoma Biomarkers in Egyptian Cohort
Although hepatocellular carcinoma (HCC) has been subjected to continuous investigation and its symptoms are well-known, early stage diagnosis of this disease remains difficult and the survival rate after diagnosis is typically very low (3−5%). Early and accurate detection of metabolic changes in the...
2013-06-30 | MTBLS19 | MetaboLights
MetabolomicsMetabolomics biomarkers of hepatocellular carcinoma in a prospective cohort of patients with cirrhosis

BACKGROUND & AIMS: The effectiveness of surveillance for hepatocellular carcinoma (HCC) in patients with cirrhosis is limited, due to inadequate risk stratification and suboptimal performance of current screening modalities.

METHODS: We developed a mult...

2024-05-09 | MTBLS8764 | MetaboLights
MetabolomicsEFO: In preparation - Early Metabolic Predictors of Type 2 Diabetes Mellitus in Normoglycemic Adults: Insights from Six-Year Prospective Cohort Study

INTRODUCTION: Type 2 Diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and hyperglycemia, often preceded by latent metabolic disruptions. Early detection of metabolic alterations can facilitate timely intervention to delay or prevent T2DM onset. Metaboli...

2025-08-04 | MTBLS10965 | MetaboLights
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