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MetabolomicsCross-modal Integration of Metabolomics and Cardiac Functionality Captures Dynamic Metabotoxic Effects of Doxorubicin in Engineered Heart Tissues

Functional stem cell-derived heart models offer new avenues for preclinical, animal-free physiological assessment of drug cardiotoxicity. Yet, comprehensive molecular profiling in these models remains limited, leaving key metabolic drivers of cardiotoxicity unexplored.

Here, we leveraged an...

2025-12-07 | MTBLS13225 | MetaboLights
ProteomicsDigital Light Processing 3D Printing Enables Versatile Fabrication of Human Engineered Heart Tissues
While cell models are routinely used to study cardiac molecular biology, in vitro systems fall far short of mimicking the metabolic and sarcomere structural maturity of intact cardiac tissue. Achieving a mature cardiomyocyte (CM) phenotype is essential for creating a physiologically relevant environ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-21 | PXD074288 | Pride
Human engineered heart tissues Digital light processing 
ProteomicsVersatile human cardiac tissues engineered with perfusable heart extracellular microenvironment for biomedical applications
Engineered human cardiac tissues have been utilized for various biomedical applications, including drug testing, disease modeling, and regenerative medicine. However, the applications of cardiac tissues derived from human pluripotent stem cells are often limited due to their immaturity and lack of f...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2024-02-03 | PXD042077 | Pride
Decellularization 
TranscriptomicsExpression data from cyclically stretched engineered neonatal rat ventricuar myocyte (NRVM) tissues
Mechanical overload in the heart induces pathological remodeling that typcially leads to heart failure. We sought to build an in vitro model of heart failure by applying cyclic stretch to engineered isotropic (iso) and anisotropic (aniso) NRVM tissues. We used micoarrays to determine the effects of ...
ORGANISM(S): Rattus norvegicus 
2013-01-30 | E-GEOD-43846 | biostudies-arrayexpress
GenomicsGene expression in engineered heart tissues exposed to THC and genistein
Gene expression in engineered heart tissues exposed to THC and genistein
PRJNA816073 | ENA
GenomicsIn vitro HFpEF human engineered heart tissues (hEHTs)
In vitro HFpEF human engineered heart tissues (hEHTs)
PRJNA1458010 | ENA
GenomicsModeling Radiation-induced Cardiovascular Dysfunction with Human iPSC-Derived Engineered Heart Tissues
Modeling Radiation-induced Cardiovascular Dysfunction with Human iPSC-Derived Engineered Heart Tissues
PRJNA1011335 | ENA
GenomicsRNA sequencing of control and dystrophin-mutant engineered heart tissues from human induced pluripotent stem cell-derived cardiomyocytes
RNA sequencing of control and dystrophin-mutant engineered heart tissues from human induced pluripotent stem cell-derived cardiomyocytes
PRJNA819019 | ENA
ProteomicsChronic activation of tubulin tyrosination in HCM mice and in human iPSC-engineered heart tissues improves heart function
Rationale Hypertrophic cardiomyopathy (HCM) is the most common cardiac genetic disorder caused by sarcomeric gene variants and is associated with left ventricular hypertrophy and diastolic dysfunction. The role of the microtubule network has recently gained interest with findings that microtubule de...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-28 | PXD054236 | Pride
Heart function  hypertrophic cardiomyopathy  engineered heart tissue  hipsc  microtubules  alpha-tubulin tyrosination and detyrosination. 
GenomicsEngineered heart tissues facilitate functional characterization of noncoding variants implicated in Hypertrophic and Dilated Cardiomyopathy
Engineered heart tissues facilitate functional characterization of noncoding variants implicated in Hypertrophic and Dilated Cardiomyopathy
PRJNA1467678 | ENA
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