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MetabolomicsTraditional Aboriginal Preparation Alters the Chemical Profile of Carica papaya Leaves and Impacts on Cytotoxicity towards Human Squamous Cell Carcinoma
Carica papaya leaf decoction, an Australian Aboriginal remedy, has been used widely for its healing capabilities against cancer, with numerous anecdotal reports. In this study we investigated its in vitro cytotoxicity on human squamous cell carcinoma cells followed by metabolomic profiling of Carica...
2017-05-04 | MTBLS274 | MetaboLights
TranscriptomicsmiR-34a is downregulated in cis-diamminedichloroplatinum treated sinonasal squamous cell carcinoma patients with poor prognosis.
For the purpose of analyzing mechanisms related to the cis-diamminedichloroplatinum (CDDP) resistance in head and neck squamous cell carcinoma (head and neck SCC), we employed a nasal squamous cell carcinoma (nasal SCC) cell line RPMI2650 and its CDDP resistant substrain RPMI2650CR previously descri...
ORGANISM(S): Homo sapiens 
2012-06-13 | E-GEOD-32176 | biostudies-arrayexpress
TranscriptomicsExpression data from oral squamous cell carcinoma cell line Cal27 after lentivirus shIL-1beta transfection
Oral squamous cell carcinoma cell line Cal27 was transfected with lentiviral shIL-1beta or scrambled shRNA. We used microarrays to detail the global program of gene expression during this process. IL-1beta was identified as one of the key node genes in oral carainogenesis in our preveious in vitro s...
ORGANISM(S): Homo sapiens 
2016-05-17 | E-GEOD-70301 | biostudies-arrayexpress
MetabolomicsSOX2 Drives Esophageal Squamous Carcinoma by Reprogramming Lipid Metabolism and Histone Acetylation Landscape

SOX2 is not only a pioneer transcription factor with critical roles in stem cell function and cell reprogramming but also a potent oncogene for a multitude of squamous cancers. How SOX2 exerts a potent oncogenic activity in squamous lineage is largely unknown. Here we uncovered SOX2 a p...

2025-08-07 | MTBLS7120 | MetaboLights
TranscriptomicsMicroRNA analysis in HPV-positive and HPV-negative cervical cancer cell lines
Persistent infection by high-risk human papillomaviruses (HPVs) is associated with the development of cervical cancer and a subset of anogenital and head and neck squamous cell carcinomas. Abnormal expression of cellular microRNAs (miRNAs) plays an important role in the development of cancer, includ...
ORGANISM(S): Homo sapiens 
2018-01-16 | E-MTAB-6361 | biostudies-arrayexpress
ProteomicsDeoxynivalenol and A431 epidermoid squamous carcinoma cells: proteomic profiling reveals the pathways connecting ribosomal inhibition with the loss of function of the cell membrane
The possibility to combine proteomics workflows to classical experimental approaches is continuously opening new insights in all branches of biological sciences. Deoxynivalenol (vomitoxin, DON) is a secondary metabolite produced by Fusarium spp. fungi and it is one of the most recurrent mycotoxins w...
ORGANISM(S): Homo sapiens (Human) 
2021-04-05 | PXD011474 | Pride
Vomitoxin)  a431 cells  phosphoproteomics Deoxynivalenol (don 
TranscriptomicsExpression data comparing KYSE-140 ESCC cell line CD90+ and CD90- cells
To identify candidate genes involved in enhanced tumorigenicity and metastasis of CD90+ esophageal tumor-initiating cells. The esophageal squamous carcinoma cell (ESCC) cell line KYSE-140 was sorted into CD90+ and CD90- populations by flow cytometry. Total RNA was analyzed on Affymetrix Human Genome...
ORGANISM(S): Homo sapiens 
2013-03-23 | E-GEOD-37949 | biostudies-arrayexpress
ProteomicsQuantitative phosphoproteomic analysis reveals system-wide signaling pathways regulated by site-specific phosphorylation on Keratin-8 in skin squamous cell carcinoma derived cell-line
The epithelial specific keratin pair, Keratin 8/18 (K8/18), has been reported to be aberrantly expressed in squamous cell carcinoma (SCC) which is also correlated with increased invasiveness and poor prognosis. A Majority of Keratin 8 (K8) functions are governed by its phosphorylation at Serine73 (...
ORGANISM(S): Homo sapiens (Human) 
2018-07-05 | PXD005301 | Pride
Keratin 8 phosphorylation Tmt based quantitative phosphoproteomics Human epidermoid carcinoma cell-line 
GenomicsmacroH2A2 overexpression in head and neck squamous cell carcinoma cell line T-HEp3.
macroH2A2 overexpression in head and neck squamous cell carcinoma cell line T-HEp3.
PRJNA756293 | ENA
TranscriptomicsTranscription profiling of human CAL 27 cells overexpressing Nm23-H1 to identify downstream targets of Nm23-H1
The human nm23-H1 was discovered as a tumor metastasis suppressor based on its reduced expression in melanoma cell lines with low versus high metastatic potential. It encodes for one of two subunits of the nucleoside-diphosphate kinase. Besides its role in the maintenance of the cells NTP pool, nm23...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-4069 | biostudies-arrayexpress
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