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TranscriptomicsMolecular profiling of functional interactions between pre-osteoblastic and breast carcinoma cells
The relationships between cancer cells and the microenvironment play a critical role in cancer growth and development. The bone stroma consists of mesenchymal stem cells (MSCs) and mature osteoblasts that promote cancer growth. Yet it is not completely understood what are the molecular processes gui...
ORGANISM(S): Mus musculus 
2014-11-23 | E-GEOD-34529 | biostudies-arrayexpress
TranscriptomicsOsteoblastic response in human bone marrow stromal cells
Our goal was to determine whether osteoblastic LuCaP 23.1 prostate cancer xenograft tumors can elicit an osteoblastic response at the gene expression level in human bone marrow stromal cells. Custom Agilent 44K whole human genome expression oligonucleotide microarrays were used to profile bone marro...
ORGANISM(S): Homo sapiens 
2013-12-23 | E-GEOD-48907 | biostudies-arrayexpress
TranscriptomicsModeling Familial Cancer with iPSC Approaches
In vitro modeling of human disease has recently become feasible with the adoption of induced pluripotent stem cell (iPSC) technology. Here, we established patient-derived iPSCs from an Li-Fraumeni Syndrome (LFS) family and investigated the role of mutant p53 in the development of osteosarcoma (OS). ...
ORGANISM(S): Homo sapiens 
2015-04-10 | E-GEOD-58123 | biostudies-arrayexpress
TranscriptomicsComparative Expression of Human-Mouse Syntenic Genes during Osteoblastic Differentiation of Bone Marrow Mesenchymal Stem Cells
Comparative analysis of differentially expressed Human-Mouse Syntenic mRNA during Osteoblastic Differentiation of Bone Marrow Mesenchymal Stem Cells
ORGANISM(S): Mus musculus 
2010-06-22 | E-MEXP-3244 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of HOS (human osteosarcoma) cells exposed to fluoride
Though fluoride is considered an essential trace element, chronic exposure to fluoride is known to cause toxic effects. Chronic exposure of high concentration of fluoride may leads to fluorosis. To understand the molecular mechanism of fluoride induced toxicity gene expression profiling was performe...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-70719 | biostudies-arrayexpress
UnknownHepatocytic Differentiation Potential of Human Fetal Liver Mesenchymal Stem Cells: In Vitro and In Vivo Evaluation.
Not available
S-EPMC4738699 | biostudies-literature
TranscriptomicsIron excess limits HHIPL2 gene expression and decreases osteoblastic activity in human MG-63 cells
Our transcriptomic data shows that iron impact on human osteoblastic MG-63 cells by decreasing HHIPL-2 gene expression (2 fold ratio). This impact is corrected in presence of deferoxamine. Additional biological experiments in the manuscript suggest that the iron related modulation of HHIPL-2 gene ...
ORGANISM(S): Homo sapiens 
2012-09-01 | E-GEOD-30774 | biostudies-arrayexpress
TranscriptomicsEarly B Cell Factor 2 Regulates Hematopoietic Stem Cell Homeostasis in a Cell-Nonautonomous Manner
Hematopoiesis requires the interaction of hematopoietic stem cells (HSCs) with various stromal microenvironments. Here, we examine the role of early B cell factor 2 (Ebf2), a transcription factor expressed in a subset of immature osteoblastic cells. Ebf2-/- mice show decreased frequencies of HSCs an...
ORGANISM(S): Mus musculus 
2011-04-26 | E-GEOD-21700 | biostudies-arrayexpress
Unknownalpha7 integrin expressing human fetal myogenic progenitors have stem cell-like properties and are capable of osteogenic differentiation.
Not available
S-EPMC2766282 | biostudies-literature
TranscriptomicsGenome-wide CpG methylation during osteogenic and myogenic differentiation from adipose- derived stem cells.
In the current study, we have performed a high-throughput CpG methylation analysis of well characterized and defined populations of human adipose-derived stem cells (hASCs) before and after in vitro induction of osteogenic and myogenic differentiation that allows identifying DNA methylation- regulat...
ORGANISM(S): Homo sapiens 
2014-01-02 | E-GEOD-33896 | biostudies-arrayexpress
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