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TranscriptomicsTranscriptomic profiling of HT1080 fibrosarcoma cells of mesenchymal or amoeboid migratory phenotype
Amoeboid and mesenchymal migration of cancer cells both contribute to metastatic spreading of tumors. To characterize gene expression profiles underlying the different migratory modes, we performed RNA sequencing of HT1080 fibrosarcoma cells undergoing mesenchymal-amoeboid transition induced by eith...
ORGANISM(S): Homo sapiens 
2019-07-29 | E-MTAB-6823 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HT1080 fibrosarcoma cells treated with cytostatic drugs
HT1080 fibrosarcoma cells were treated with cytostatic drugs and analysed on Affymetrix microarray to identify genes and pathways regulated by these compounds. The array images were processed using Affymetrix MAS 5.0 software. and normalized by global scaling or scaled to a polyA+ spike mask
ORGANISM(S): Homo sapiens 
2008-04-01 | E-GEOD-2238 | biostudies-arrayexpress
TranscriptomicsGene expression microarray of HT1080 cell line
Analysis of the effects of genomic elements, gene transcritpion, and DNA replication on gene targeting. The hypothesis tested was that genomic elements and processes either positively or megatively influence AAV-mediated gene targeting. Results show that homologous recombination increases when the...
ORGANISM(S): Homo sapiens 
2014-07-31 | E-GEOD-58968 | biostudies-arrayexpress
TranscriptomicsExpression data from RECK-overexpressing HT1080 fibrosarcoma cells
RECK, a glycosylphosphatidylinositol-anchored glycoprotein, inhibits the enzymatic activities of some matrix metalloproteinases (MMP), thereby suppressing tumor cell metastasis; however, the detailed mechanism is still obscure. In this study, we compared the gene expression profiles between mock- an...
ORGANISM(S): Homo sapiens 
2010-04-14 | E-GEOD-21306 | biostudies-arrayexpress
GenomicsHomo sapiens strain:HT1080
Methylome in human cells expressing mycoplasmal DNA methyltransferases
PRJNA233511 | ENA
TranscriptomicsExpression analysis of human CRABP1 gene and R131A CRABP1 mutant in HT1080 cells
Investigation of whole genome gene expression level changes in HT1080 fibrosarcoma cell line after transfection CRABP1 gene and R131A CRABP1 mutant (arginine-alanine substitution in a protein active site, protein lacks the ability to interact with retinoic acid), compared to HT1080 line transfected ...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-48673 | biostudies-arrayexpress
TranscriptomicsTranscriptome of human HT1080 cells treated with purified Salmonella Typhi toxin
Aim of the experiment: To examine changes in gene expression in HT1080 fibroblasts following treatment with purified recombinant wild-type typhoid toxin (TOX) from Salmonella Typhi relative to a mutant H160Q variant lacking DNase activity (TOX-H160Q). Experimental workflow: HT1080 were seeded one d...
ORGANISM(S): Homo sapiens 
2022-10-14 | E-MTAB-12333 | biostudies-arrayexpress
TranscriptomicsSuppression of IFN-induced transcription underlies IFN defects generated by activated Ras/MEK in human cancer cells
Certain oncolytic viruses exploit activated Ras signalling in order to replicate in cancer cells. Constitutive activation of the Ras/MEK pathway is known to suppress the effectiveness of the interferon (IFN) antiviral response, which may contribute to Ras-dependent viral oncolysis. Here, we identifi...
ORGANISM(S): Homo sapiens 
2012-08-02 | E-GEOD-31019 | biostudies-arrayexpress
GenomicsEffects of IFN beta treatment on gene expression in human fibrosarcoma HT1080 cells
Effects of IFN beta treatment on gene expression in human fibrosarcoma HT1080 cells
PRJNA1217059 | ENA
GenomicsGenome binding profile of TFIIH helicases XPB and XPD in HT1080 cells
The conserved TFIIH helicases XPB and XPD play key roles in transcription initiation and DNA repair. To investigate the functions of these helicases on a genome-wide scale, we performed ChIP-seq of endogenous XPB and XPD in the HT1080 human fibrosarcoma cell line. 2 ChIP samples and 1 unenriched inp...
ORGANISM(S): Homo sapiens 
2014-02-18 | E-GEOD-44849 | biostudies-arrayexpress
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