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TranscriptomicsTranscription profiling by array of human myeloma cell lines
30 human myeloma cell lines
ORGANISM(S): Homo sapiens 
2010-12-23 | E-TABM-1088 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human CD138 purified bone marrow plasma cells, CD27 memory B-cells, polyclonal plasmablastic cells and human myeloma cell lines
Gene expression profiling of CD138 purified bone marrow plasma cells of healthy donors, CD27 memory B-cells, cultured ployclonal plasmablastic cells and cultured human myeloma cell lines. Samples from healthy donors have been re-used from ArrayExpress experiment E-MEXP-2360. Some of the myeloma cell...
ORGANISM(S): Homo sapiens 
2017-02-23 | E-MTAB-5212 | biostudies-arrayexpress
TranscriptomicsHypoxia-inducible factor (Hif)-1 knockdown blocks tumor growth, myeloma-induced angiogenesis and bone destruction in vivo
In multiple myeloma (MM), hypoxia-inducible transcription factor-1 (HIF-1) is overexpressed in the MM cells of the hypoxic bone marrow (BM) microenvironment. Herein, we explored in MM cells the in vitro and in vivo effects of persistent HIF-1 inhibition by expression of a lentivirus shRNA pool on pr...
ORGANISM(S): Homo sapiens 
2013-04-01 | E-GEOD-40326 | biostudies-arrayexpress
TranscriptomicsBortezomib inhibits mTOR pathway in multiple myeloma cells via induced expression of REDD1.
The combination of bortezomib and dexamethasone should become the reference induction treatment for multiple myeloma patients younger than 65 years. Pharmacogenomic profiles of genes involved in response to treatment may help to understand resistance. We performed gene expression profiling in 9 myel...
ORGANISM(S): Homo sapiens 
2010-02-14 | E-GEOD-11866 | biostudies-arrayexpress
GenomicsTranscriptomics changes upon WNK1 knockdown in JJN3 cells
Transcriptomics changes upon WNK1 knockdown in JJN3 cells
PRJNA1024367 | ENA
GenomicsTranscriptomics changes upon WNK463 treatment in JJN3 cells
Transcriptomics changes upon WNK463 treatment in JJN3 cells
PRJNA1024365 | ENA
TranscriptomicsIntegrative genomic approach reveals expression of intronic miR-335, miR-342, and miR-561 in multiple myeloma
The role of microRNAs (miRNAs) in multiple myeloma (MM) has yet to be fully elucidated. To identify miRNAs that are potentially deregulated in MM, we investigated those mapping within transcription units, based on evidence that intronic miRNAs are frequently coexpressed with their host genes. To thi...
ORGANISM(S): Homo sapiens 
2008-11-10 | E-GEOD-11522 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human multiple myeloma cell lines JJN3, OPM2 and XG7 with PRMT5 inhibitor EPZ015938 versus untreated controls.
Evaluation of anti-myeloma effects of inhibition of PRMT5, involved in arginine methylation. Three human multiple myeloma cell lines were treated with the PRMT5 inhibitor EPZ015938. Transcriptional profiles were compared to untreated controls.
ORGANISM(S): Homo sapiens 
2022-03-11 | E-MTAB-11489 | biostudies-arrayexpress
TranscriptomicsExpression data from human multiple myeloma cells with or without IRE1-XBP1 silencing
We used microarrays to develop gene signatures for XBP1 and IRE1 in myeloma cells to explore the role of this UPR/differentiation pathway in proteasome inhibitor resistance. RPMI-8226 and JJN3 human myeloma cells were infected with lentivirus expressing non-targeted (NT) shRNA, shIRE1 or shXBP1 and ...
ORGANISM(S): Homo sapiens 
2013-03-09 | E-GEOD-44968 | biostudies-arrayexpress
TranscriptomicsTranscriptomics changes upon WNK463 treatment in JJN3 cells
We performed RNA-seq in JJN3 human multiple myeloma cells treated with WNK463 to profile global transcriptomic changes
ORGANISM(S): Homo sapiens 
2024-04-16 | GSE244667 | GEO
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