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MetabolomicsPharmacological Targeting of ALDH1a2 in Dendritic Cells Enhances Antigen Presentation, T Cell Activation and Anti-tumor immunity
Dendritic cell (DC) vaccines have been proposed as cancer immunotherapies due to their role as crucial antigen-presenting cells that regulate T cell functions. Despite considerable efforts to optimize ex vivo priming of DCs, DC vaccines have rarely been successful, suggesting the presence of unknown...
2025-11-03 | MTBLS10389 | MetaboLights
ProteomicsCrosslinking MS of Antibody-HLA-A*11:01
Cross-linking mass spectrometry data of cross-linked antibody to human leukocyte antigen (HLA-A*11:01). For antibodies 2E3, 1E3 and 3H10.
ORGANISM(S): Homo Sapiens (human) 
2023-11-23 | PXD038059 | JPOST Repository
ProteomicsSampling from proteome to HLA-DR ligandome
Comprehensive analysis of the complex nature of the Human Leukocyte Antigen (HLA) class II ligandome is of utmost importance to understand the basis for CD4+ T cell mediated immunity and tolerance. Here, we implemented important improvements in the analysis of the repertoire of HLA-DR-presented pept...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-08-24 | MSV000082848 | MassIVE
GenomicsPan cancer investigation of human leukocyte antigen loss of heterozygosity
Pan cancer investigation of human leukocyte antigen loss of heterozygosity
PRJNA800571 | ENA
GenomicsPan cancer investigation of human leukocyte antigen loss of heterozygosity
Pan cancer investigation of human leukocyte antigen loss of heterozygosity
PRJNA800572 | ENA
ProteomicsPresentation of the Extra-Cellular Domain of the Sars2 Spike Glycoprotein by Immunopeptidomic Profiling of HLA-II Bound Peptides from Human Dendritic Cells
In the present study we sought to identify the naturally processed and presented immunopeptidome of the SARS-CoV-2 spike glycoprotein from human antigen presenting cells. Monocyte-derived dendritic cells from a panel of healthy human subjects representing a majority of the HLA-DRB1 allele usage with...
ORGANISM(S): Sars Coronavirus (ncbitaxon:227859) Bos (ncbitaxon:9903) Homo Sapiens (ncbitaxon:9606) 
2020-05-21 | MSV000085456 | MassIVE
TranscriptomicsTranscription profiling of human lymphatic endothelial cells, mouse dermal cells and human skin cells reveals an inflammation-induced mechanism for leukocyte transmigration of lymphatic vessel endothelium.
The exit of antigen-presenting cells (APC) and lymphocytes from inflamed skin to afferent lymph is vital for the initiation and maintenance of dermal immune responses. How such exit is achieved and how cells transmigrate the distinct endothelium of lymphatic vessels is however unknown. Here we show ...
ORGANISM(S): Homo sapiens 
2008-11-07 | E-GEOD-6257 | biostudies-arrayexpress
MetabolomicsProduction of new microbially conjugated bile acids by human gut microbiota

Gut microbes have been recognized to convert the human bile acids by deconjugation, dehydroxylation, dehydrogenation and epimerization of the cholesterol core, but the ability to re-conjugate them with amino acids as an additional conversion has only been recently described. These new bile acids ...

2024-01-16 | MTBLS4140 | MetaboLights
UnknownSimultaneous genotyping for human platelet antigen systems and HLA-A and HLA-B loci by targeted next-generation sequencing.
Not available
S-EPMC9575554 | biostudies-literature
MetabolomicsMTBLS12814: Characterizing Human Oxidative, Anabolic and Glycolytic Metabolism in Athletes with Extreme Physiologies

Background

Regular physical activity is known to benefit health but the long-term effects of specific exercise training on human metabolism remain incompletely described. In this study, we comprehensively characterized the blood metabolomes of male athletes with distinct exercise-adapted me...

2026-03-13 | MTBLS12814 | MetaboLights
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