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TranscriptomicsWhole genome expression signature of SWCNT and MWCNT vs. asbestos subchronic exposures to human pleural mesothelial cells
Malignant mesothelioma is one of the most aggressive forms of cancer known. Recent studies have shown that carbon nanotubes (CNTs) are biopersistent and induce mesothelioma in animals, but the underlying mechanisms are not known. Here, we investigate the effect of long-term exposure to CNTs on the a...
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-48855 | biostudies-arrayexpress
ProteomicsPrimary and hTERT-transduced mesothelioma-associated fibroblasts but not primary or hTERT-transduced mesothelial cells stimulate growth of human mesothelioma cells_Secreted proteins
Introduction: Pleural mesothelioma (PM) is known as one of the most aggressive malignancies among all cancers, despite of usually absent tumor-driver mutations in oncogenes. It develops in a unique inflammatory tumor microenvironment (TME), which has been postulated as major contributor of PM’s high...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD043511 | Pride
Htert Mesothelioma-associated fibroblasts Pleural mesothelial cells Pleural mesothelioma Conditioned medium Human telomerase reverse transcriptase Tumor microenvironment 
TranscriptomicsAlterations in Gene Expression in Human Mesothelial Cells Correlate with Mineral Pathogenicity
Human mesothelial cells (LP9/TERT-1) were exposed to low and high (15 and 75 μm2/cm2 dish) equal surface area concentrations of crocidolite asbestos, nonfibrous talc, fine titanium dioxide (TiO2), or glass beads for 8 or 24 h. RNA was then isolated for Affymetrix microarrays, GeneSifter analysis and...
ORGANISM(S): Homo sapiens 
2011-09-18 | E-GEOD-14034 | biostudies-arrayexpress
ProteomicsPrimary and hTERT-transduced mesothelioma-associated fibroblasts but not primary or hTERT-transduced mesothelial cells stimulate growth of human mesothelioma cells_ Cytoplasmic proteins & Proteins from nuclear extracts
Introduction: Pleural mesothelioma (PM) is known as one of the most aggressive malignancies among all cancers, despite of usually absent tumor-driver mutations in oncogenes. It develops in a unique inflammatory tumor microenvironment (TME), which has been postulated as major contributor of PM’s high...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD043534 | Pride
Htert Mesothelioma-associated fibroblasts Pleural mesothelial cells Pleural mesothelioma Conditioned medium Human telomerase reverse transcriptase Tumor microenvironment 
TranscriptomicsTranscription profiling of human mesothelioma cells MPP-89 REN compared to mesothelial cells HMC-TERT
gene expression profile of mesothelioma cells (MPP-89; REN) compared to mesothelial cells (HMC-TERT)
ORGANISM(S): Homo sapiens 
2008-10-09 | E-MEXP-1701 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human mesothelioma cells (MPP-89, REN) compared to mesothelial cells (HMC-TERT)
gene expression profiles of mesothelioma cells (MPP-89, REN) compared to mesothelial cells (HMC-TERT)
ORGANISM(S): Homo sapiens 
2008-10-09 | E-MEXP-1700 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of two mesothelioma cell lines (MPP89 and REN), and of HMC-TERT non tumoral mesothelial cells
miRNA profile analysis of two mesothelioma cell lines (MPP89 and REN), and of HMC-TERT non tumoral mesothelial cells
ORGANISM(S): Homo sapiens 
2008-10-09 | E-MEXP-1699 | biostudies-arrayexpress
TranscriptomicsIdentification of novel markers of the mesothelial lineage and mesothelioma
Microarray expression arrays on mesothelium and other tissues dissected from mice were used to identify candidate mesothelial lineage markers. These were then tested by qRTPCR across a panel of human mesothelioma cells lines, other cancers, and normal primary cells includidng mesothelial cells. Twen...
ORGANISM(S): Mus musculus 
2011-12-18 | E-GEOD-30793 | biostudies-arrayexpress
ProteomicsCharacterization of fibrosis and senescence of human omental peritoneal mesothelial cells
Primary human omental mesothelial cells from multiple donors in a young (=normal) phase and senescent phase were treated with or without TGF-ß to induce fibrosis. Senescence was induced by up to 9 passages and confirmed by stopped cell division and positive senescence-associated β-galactosidase stai...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD048090 | Pride
Fibrosis Peritoneal dialysis Senescence 
TranscriptomicsHuman peritoneal mesothelial cell response to conditioned media of BCAM overexpressing OVCAR8 cells (genetic modification)
Human peritoneal mesothelial cells (HPMCs) were incubated with the conditioned media collected from tumor cells genetically modified to overexpress BCAM.
ORGANISM(S): Homo sapiens 
2025-12-31 | E-MTAB-14412 | biostudies-arrayexpress
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