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MetabolomicsMetabonomic analysis of human and 12 kinds of livestock mature milk

Mature milk, as a nutrient-rich endogenous metabolite, has various beneficial effects on the human body. In order to investigate the specific nutrients provided by different dairy products to humans, we used UHPLC-Q-TOF MS to analyze the highly significantly differentially expressed metabolites i...

2023-08-21 | MTBLS6777 | MetaboLights
MetabolomicsEvaluation of sample preparation methods for NMR-based metabolomics of cow milk
The quality of milk metabolome analyzed by nuclear magnetic resonance (NMR) is greatly influenced by the way samples are prepared. Although this analytical method is increasingly used to study milk metabolites, a thorough examination of available sample preparation protocols for milk has not been re...
2019-06-13 | MTBLS623 | MetaboLights
MetabolomicsHuman milk as infantile Super Food - the effect of dietary choices and supplementation on the shift of lipidomic profile during different stages of lactation
The objective of this project was to establish an advanced analytical method leveraging high-resolution mass spectrometry LC-HRMS to comprehensively profile the human milk lipidome. Mass spectrometry resolves and quantifies compounds based on a fundamental physical metric: the mass-to-charge ratio. ...
2026-09-22 | MTBLS15678 | MetaboLights
MetabolomicsHuman Milk-Derived 5′-UMP Promotes Thermogenesis and Mitochondrial Biogenesis to Ameliorate obesity

Background: Traditional obesity interventions are often unsuitable for children. Breastfeeding has been shown to reduce obesity risk, potentially through bioactive metabolites in human milk. Here, we identified a human milk-derived metabolite, uridine 5'-monophosphate (5'-UMP), whose role in lipi...

2025-09-23 | MTBLS13027 | MetaboLights
MetabolomicsIntegrated microbiome and metabolome analysis of milk of lactational mastitis women in remission period
Lactational mastitis is a disease that brings pain to mothers and interrupts breastfeeding. After remission, mothers and doctors care about whether the milk is suitable to continue breastfeeding or not. However, relevant research, particularly multi-omics studies focusing on the remission phase of l...
2026-04-01 | MTBLS14200 | MetaboLights
MetabolomicsExploring the Fecal Metabolome in Infants With Cow's Milk Allergy: The Distinct Impacts of Cow's Milk Protein Tolerance Acquisition and of Synbiotic Supplementation.

SCOPE: Cow's milk allergy (CMA) is one of the most prevalent food allergies in early childhood, often treated via elimination diets including standard amino acid-based formula or amino acid-based formula supplemented with synbiotics (AAF or AAF-S). This work aimed to assess ...

2024-09-02 | MTBLS8954 | MetaboLights
TranscriptomicsRNA-sequencing of the human milk fat layer during colostrum, transitional, and mature stages of lactation
Human milk fat globules, by enveloping cell contents during their secretion into milk, are a rich source of mammary cell RNA. Here, we pair this non-invasive mRNA source with RNA sequencing technology to probe the milk fat layer transcriptome during three stages of lactation: colostral, transitional...
ORGANISM(S): Homo sapiens 
2013-07-22 | E-GEOD-45669 | biostudies-arrayexpress
ProteomicsProteomic Characterization of Human Milk Fat Globule Membrane Proteins during a 12 Month Lactation Period
The milk fat globule membrane (MFGM) contains proteins which have been implicated in a variety of health benefits. Milk fat globule membrane proteins were isolated from human milk during a 12 month lactation period and subjected to in solution digestion and liquid chromatography tandem mass spectrom...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-24 | MSV000089722 | MassIVE
ProteomicsDiscovery and quantification of non-human proteins in human milk
The question whether and which non-human peptides or proteins are present in human milk was raised many decades ago. However, due to cross-reactivity or nonspecific antibody recognition, the accuracy of detection by immunochemical methods has been a concern. Additionally, the relative low-abundance ...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Felis catus (Cat) (Felis silvestris catus) Canis familiaris (Dog) (Canis lupus familiaris) Gallus gallus (Chicken) Oryza sativa (Rice) Equus caballus (Horse) 
2018-12-04 | PXD011599 | Pride
Non-human peptides Shotgun proteomics Human milk Mass spectrometry Non-human proteins Parallel reaction monitoring 
ProteomicsWhole milk proteome of human and rhesus macaque during peak lactation
Milk has been well established as the optimal nutrition source for infants, yet there is still much to be understood about its molecular composition. Therefore, our objective was to develop and compare comprehensive milk proteomes for human and rhesus macaques to highlight differences in neonatal nu...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Macaca Mulatta (ncbitaxon:9544) 
2015-02-23 | MSV000079045 | MassIVE
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