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ProteomicsDifferential alkylation of PHLPP2
To determine the accessibility of cysteines in purified PHLPP2, we assessed their reactivity with iodoacetamide under native conditions. After denaturing with urea and reducing potential disulfide bridges with TCEP, the remaining free cysteines were modified with methyl methanethiosulfonate. This 2-...
ORGANISM(S): Homo sapiens (Human) 
2025-03-13 | PXD052551 | Pride
Differential alkylation Free thiols 
ProteomicsPeptide fingerprinting of purified recombinant human PHLPP2
Peptide fingerprinting to establish whether there is any contaminating phosphatase(s) in the purified protein.
ORGANISM(S): Homo sapiens (Human) Spodoptera frugiperda 
2025-03-13 | PXD045978 | Pride
Human phlpp2 
GenomicsPHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor
PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor
PRJNA1214704 | ENA
UnknownPhosphatase PHLPP2 regulates the cellular response to metabolic stress through AMPK.
Not available
S-EPMC8490465 | biostudies-literature
TranscriptomicsPHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor
The phosphoinositide 3-kinase (PI3K) pathway is a major regulator of cell and organismal growth. Consequently, hyperactivation of PI3K and its downstream effector kinase, Akt, is observed in many human cancers. PH domain leucine-rich repeat-containing protein phosphatases (PHLPP), two paralogous mem...
ORGANISM(S): Homo sapiens 
2025-04-02 | GSE287792 | GEO
UnknownCheliensisin A (Chel A) induces apoptosis in human bladder cancer cells by promoting PHLPP2 protein degradation.
Not available
S-EPMC5341830 | biostudies-literature
UnknownPHLPP2 stabilization by p27 mediates its inhibition of bladder cancer invasion by promoting autophagic degradation of MMP2 protein.
Not available
S-EPMC6202328 | biostudies-literature
UnknownOncogenic role of MIR516A in human bladder cancer was mediated by its attenuating PHLPP2 expression and BECN1-dependent autophagy.
Not available
S-EPMC8078721 | biostudies-literature
UnknownPHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE Exposure.
Not available
S-EPMC4682561 | biostudies-literature
UnknownTRIM22 induces cellular senescence by targeting PHLPP2 in hepatocellular carcinoma.
Not available
S-EPMC10781680 | biostudies-literature
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