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ProteomicsExtracellular matrix analysis of human keloid scars
Fibrosis is vaguely described as connective tissue deposition that can be excessive in pathological conditions. This suggests a quantitative spectrum of fibrosis wherein there can be more or less extracellular matrix (ECM), which in the context of a repairing skin wound could reflect the range from ...
ORGANISM(S): Homo sapiens (Human) 
2019-12-03 | PXD015057 | Pride
Human skin scar dermis lc-ms/ms 
ProteomicsProteomics-based insights into mitogen-activated protein kinase inhibitor resistance of cerebral melanoma metastases
Background MAP kinase inhibitor (MAPKi) therapy for BRAF mutated melanoma is characterized by high response rates but also development of drug resistance within a median progression-free survival (PFS) of 9 to 12 months. Understanding mechanisms of resistance and identifying effective therapeutic al...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000082948 | MassIVE
ProteomicsProteogenomic Identification and Validation of Key Differentially Expressed Molecular Targets for Keloid Disease
The study incorporated 5 keloid disease (KD) and 5 normal skin (NS) samples, and due to challenges in obtaining primary samples, we had a sample size of 3 biological replicates for FKN, 3 for DFSP made up of 2 primary cells and 1 cell line, and 2 Fibrosarcoma cell lines FS-CL-1 (HT-1080 [HT1080], C...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-29 | MSV000091168 | MassIVE
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