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MetabolomicsMetabolomics Analysis of the Effect of GAT-2 Deficiency on Th1 Cells in Mice

The classic neurotransmitter gamma-aminobutyric acid (GABA) has been shown to shape the activation and function of immune cells. There are four high affinity GABA transporters (GATs, including GAT-1, GAT-2, GAT-3 and GAT-4) responsible for the transmembrane transport of GABA in mice. To explore t...

2021-10-14 | MTBLS3358 | MetaboLights
ProteomicsReference proteome of highly purified human Th1 cells reveals strong effects on metabolism and protein ubiquitination upon differentiation
The differentiation of human CD4+ T cells into different subtypes of T helper cells and regulatory T cells is crucial for an appropriate immunological response. Among all subtypes Th1 cells are the most prominent specific cell type, representing about 50% of all lymphocytes. So far most global prote...
ORGANISM(S): Homo sapiens (Human) 
2015-10-13 | PXD001066 | Pride
Th1 cells Cd4+ Human Lc-ms/ms 
TranscriptomicsCXCR3+ Treg cells suppress Th1-immune responses through expression of the co-inhibitory receptors CD85k and Lag-3
CD4+Foxp3+ Treg cells are essential for maintaining self-tolerance and preventing excessive immune responses. In the context of Th1 immune responses, co-expression of the Th1 transcription factor T-bet with Foxp3 is essential for Treg cells to control Th1 responses. T-bet-dependent expression of CXC...
ORGANISM(S): Mus musculus 
2018-06-30 | E-MTAB-6156 | biostudies-arrayexpress
TranscriptomicsGeneration and purification of Th1 and Th2 effector and memory CD4+ T cells
Naïve CD4+ T cells were isolated from spleen of AND TcR transgenic/green fluorescence protein (GFP) transgenic mice (Kaye et al., Nature 1989;341:746, Wright et al, Blood 2001;97:2278) that recognize a peptide of pigeon cytochrome C in the context of I-Ek and express CD44lo, CD62Lhi, CD45RBhi, and ...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-8352 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of human in vitro primed Th1, Th2, Th9 and Treg T cells
To test whether human in vitro primed Th9 cells recapitulate the core pathogenic Th2 cell phenotype, we differentiated naïve T cells into Th1 (IL-12), Th2 (IL-4), Th9 (IL-4+TGF-β), and iTreg (TGF-β). After 7 days transcriptomic profiling by bulk RNA-seq was performed.
ORGANISM(S): Homo sapiens 
2022-10-31 | E-MTAB-12199 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Th cells induced to polarize to Th1 or Th2 direction in the presence or absence of TGFbeta
Th1 and Th2 cells arise from a common precursor cell in response to triggering through the TCR and cytokine receptors for IL-12 or IL-4. This leads to activation of complex signaling pathways, which are not known in detail. Disturbances in the balance between type 1 and type 2 responses can lead to ...
ORGANISM(S): Homo sapiens 
2007-12-12 | E-GEOD-2770 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing of pathogenic and non pathogenic Th1 and Th17 cell subsets
Th1 and Th17 cell subsets were sort-purified (FACSAria III, BD Biosciences, or Aurora CS, Cytek) from peripheral blood of HD and CF patients, or from lung-tissues of CF and non-CF patients, according to the expression of specific surface markers combination among CD4+IL-7R+CD25low cells: CCR6-CXCR3...
ORGANISM(S): Homo sapiens 
2026-07-14 | E-MTAB-15774 | biostudies-arrayexpress
GenomicsA molecular signature for IL-10-producing Th1 cells in protozoan parasitic diseases
Control of the intracellular parasites that cause malaria and visceral leishmaniasis (VL) is dependent on the generation of pro-inflammatory, IFNγ+ Tbet+ CD4+ T (Th1) cells by infected hosts. Immunoregulatory IL-10 produced by Th1 cells serves to mitigate subsequent inflammation and related disea...
EGAS00001004454 | EGA
TranscriptomicsExpression data from human Th1 and Th1Th17 cells
We previously demonstrated that Th1Th17 cells are highly permissive to HIV-1, whereas Th1 cells are relatively resistant. Here, we investigated molecular mechanisms underlying these differences. Superior HIV replication in Th1Th17 vs. Th1 cells was regulated by entry and post-entry mechanisms. We us...
ORGANISM(S): Homo sapiens 
2013-08-26 | E-GEOD-50175 | biostudies-arrayexpress
TranscriptomicsTCR sequencing of pathogenic and non pathogenic Th1 and Th17 cells subsets
Th1 and Th17 cell subsets were sort-purified (FACSAria III, BD Biosciences, or Aurora CS, Cytek) from peripheral blood of HD and CF patients, or from lung-tissues of CF and non-CF patients, according to the expression of specific surface markers combination among CD4+IL-7R+CD25low cells: CCR6-CXCR3...
ORGANISM(S): Homo sapiens 
2026-07-14 | E-MTAB-15769 | biostudies-arrayexpress
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