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TranscriptomicsTranscriptome-driven constraint-based modelling reveals metabolic targets for ovarian cancer
OV56 ovarian cancer cell line treated with siTPI1 (siRNA targeted against triose phosphate isomerase 1) and the following negative controls: NTsiRNA (non-targeting siRNA), transfection reagent only and untreated. Experiment designed to assess the effect of TPI1 gene knockdown on OV56 gene expression...
ORGANISM(S): Homo sapiens 
2026-04-09 | E-MTAB-16770 | biostudies-arrayexpress
ProteomicsPharmacoproteomic characterisation of human colon and rectal cancer - CRC65 Full Proteomes
Most molecular cancer therapies act on protein targets but data on the proteome status of patients and cellular models are only beginning to emerge. Here, we profiled the proteomes of 65 colorectal cancer (CRC) cell lines to a depth of >10,000 proteins using mass spectrometry. Integration with prote...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-23 | MSV000081738 | MassIVE
ProteomicsPharmacoproteomic characterisation of human colon and rectal cancer - CPTAC Full Proteomes
Most molecular cancer therapies act on protein targets but data on the proteome status of patients and cellular models are only beginning to emerge. Here, we profiled the proteomes of 65 colorectal cancer (CRC) cell lines to a depth of >10,000 proteins using mass spectrometry. Integration with prote...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-23 | MSV000081739 | MassIVE
ProteomicsPharmacoproteomic characterisation of human colon and rectal cancer - CRC65 Kinobeads
Most molecular cancer therapies act on protein targets but data on the proteome status of patients and cellular models are only beginning to emerge. Here, we profiled the proteomes of 65 colorectal cancer (CRC) cell lines to a depth of >10,000 proteins using mass spectrometry. Integration with prote...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-23 | MSV000081735 | MassIVE
GenomicsZFHX4 and CHD4 ChIP sequencing in glioblastoma tumor initiating cells
Glioblastomas (GBM) harbor subpopulations of therapy-resistant tumor initiating cells (TICs) that are self-renewing and multipotent. To understand the regulation of the TIC state, we performed an image-based screen for genes regulating GBM TIC maintenance and identified ZFHX4, a 397-kDa transcriptio...
ORGANISM(S): Homo sapiens 
2014-01-16 | E-GEOD-52419 | biostudies-arrayexpress
TranscriptomicsAn RNAi Screen Identifies TRRAP as a Regulator of Brain Tumor-Initiating Cell Differentiation
Glioblastoma multiforme is the most common and most aggressive type of primary brain tumor. The brain-infiltrative character of glioblastoma makes complete surgical removal of the tumor impossible and neither radiation nor current chemotherapy provide cure. Recent evidence shows that glioblastoma mu...
ORGANISM(S): Homo sapiens 
2011-03-14 | E-GEOD-27931 | biostudies-arrayexpress
GenomicsDeterminants of nucleosome organization in primary human cells
Genome-wide maps of nucleosome organization in human CD4+ T-cells, CD8+ T-cells, granulocytes, and from in vitro reconstitution. 8 samples include: nucleosome-bound DNA isolated from primary human CD4+ T-cells, nucleosome bound-DNA isolated from primary human CD8+ T-cells, nucleosome-bound DNA isola...
ORGANISM(S): Homo sapiens 
2011-04-19 | E-GEOD-25133 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human A549 lung cancer cells treated with actinomycin D and sapphyrin PCI-2050 a new class of tumor-selective inhibitors of gene expression.
The goal of this project was to characterize changes in gene expression in response to the anti-cancer agent sapphyrin PCI-2050. Cultured A549 human lung cancer cells were treated with sapphyrin PCI-2050 or actinomycin D.
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-6400 | biostudies-arrayexpress
GenomicsModelling HNSCC in mice with hyperactivated NRF2 pathway
Modelling HNSCC in mice with hyperactivated NRF2 pathway
PRJNA1287799 | ENA
TranscriptomicsGene expression profiling of anti-human VEGF-treated tumor xenografts formed by IGROV-1 or SKOV3 cells
This microarray experiment was designed to identify genes and pathways modulated in ovarian cancer xenografts treated with anti-human VEGF mAb (Bevacizumab). Tumors were established in NOD/SCID mice by s.c. injection of human ovarian cancer cells (IGROV-1 and SKOV3). Mice were treated with the anti-...
ORGANISM(S): Homo sapiens 
2019-12-16 | E-MTAB-7683 | biostudies-arrayexpress
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