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TranscriptomicsExpression response of human monocyte derived macrophages to dexamethasone over a 24h time series
Macrophages are amongst the major targets of glucocorticoids (GC) as therapeutic anti-inflammatory agents. Here we show that GC treatment of mouse and human macrophages initiates a cascade of induced gene expression including many anti-inflammatory genes. Inducible binding of the glucocorticoid rec...
ORGANISM(S): Homo sapiens 
2015-12-17 | E-GEOD-61880 | biostudies-arrayexpress
TranscriptomicsExpression data from a 24h time series of dexamethasone treatment for mouse bone marrow derived macrophages
Macrophages are amongst the major targets of glucocorticoids (GC) as therapeutic anti-inflammatory agents. Here we show that GC treatment of mouse and human macrophages initiates a cascade of induced gene expression including many anti-inflammatory genes. Inducible binding of the glucocorticoid rec...
ORGANISM(S): Mus musculus 
2015-12-17 | E-GEOD-61879 | biostudies-arrayexpress
GenomicsGenome wide binding of glucocorticoid receptor in dexamethasone treated human monocyte derived macrophages
Macrophages are amongst the major targets of glucocorticoids (GC) as therapeutic anti-inflammatory agents. Here we show that GC treatment of mouse and human macrophages initiates a cascade of induced gene expression including many anti-inflammatory genes. Inducible binding of the glucocorticoid rec...
ORGANISM(S): Homo sapiens 
2015-12-17 | E-GEOD-61878 | biostudies-arrayexpress
GenomicsGenome wide binding of glucocorticoid receptor in dexamethasone treated mouse bone marrow derived macrophages
Macrophages are amongst the major targets of glucocorticoids (GC) as therapeutic anti-inflammatory agents. Here we show that GC treatment of mouse and human macrophages initiates a cascade of induced gene expression including many anti-inflammatory genes. Inducible binding of the glucocorticoid rec...
ORGANISM(S): Mus musculus 
2015-12-17 | E-GEOD-61877 | biostudies-arrayexpress
TranscriptomicsEpigenetic events in early breast cancer
Subpopulations of primary Human Mammary Epithelial Cells (HMEC) have the unique ability to escape a period of growth arrest and continue to proliferate. These cells, called post-selection or variant cells (vHMEC), share features with premalignant breast cancer lesions, including p16INK4A promoter h...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-8007 | biostudies-arrayexpress
TranscriptomicsTemporal gene expression profiling of myeloid cells during the peritoneal foreign body response
This study dermined the temporal gene expression profile of myeloid subpopulations recruited to the peritoneal cavity to encapsulate implanted foreign material. Sterile foreign objects were inserted into the peritoneal cavities of MacGreen mice (in which the Csf1r promoter directs myeloid-specific ...
ORGANISM(S): Mus musculus 
2014-09-17 | E-GEOD-53101 | biostudies-arrayexpress
TranscriptomicsMacrophage response to lipopolysaccharide
Temporal analysis of bone marrow derived macrophages after 10 ug/ml lipopolysaccharide stimulation. C57BL6, C3H/ARC, BalbC and C3H/HeJ mouse strains analyzed. Each time point stimulated with 10ug/ml LPS from Salmonella minnesota for the time indicated. The RNA from each BMM stimulated time point was...
ORGANISM(S): Mus musculus 
2010-07-01 | E-GEOD-3148 | biostudies-arrayexpress
TranscriptomicsBMM_C3H/HeJ_LPS_timecourse
Bone marrow derived macrophages (BMM) total RNA from C3H/ARC mice extracted after stimulation by LPS at different time points. Each time point stimulated with 10ug/ml LPS from Salmonella minnesota for the time indicated. The RNA from each BMM stimulated time point was labeled with Cy3 and compared w...
ORGANISM(S): Mus musculus 
2010-06-05 | E-GEOD-326 | biostudies-arrayexpress
TranscriptomicsBMM_BalbC_LPS_timecourse
Bone marrow derived macrophages (BMM) total RNA from C3H/ARC mice extracted after stimulation by LPS at different time points. Each time point stimulated with 10ug/ml LPS from Salmonella minnesota for the time indicated. The RNA from each BMM stimulated time point was labeled with Cy3 and compared w...
ORGANISM(S): Mus musculus 
2003-03-27 | E-GEOD-325 | biostudies-arrayexpress
TranscriptomicsBMM_C3H/ARC_LPS_timecourse
Bone marrow derived macrophages (BMM) total RNA from C3H/ARC mice extracted after stimulation by LPS at different time points. Each time point stimulated with 10ug/ml LPS from Salmonella minnesota for the time indicated. The RNA from each BMM stimulated time point was labeled with Cy3 and compared w...
ORGANISM(S): Mus musculus 
2010-06-05 | E-GEOD-324 | biostudies-arrayexpress
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