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MetabolomicsMitochondrial respiration in B lymphocytes is essential for humoral immunity by controlling flux of the TCA cycle

To elucidate the function of oxidative phosphorylation (OxPhos) during B-cell differentiation we employ CD23Cre-driven expression of the dominant-negative K320E mutant of the mitochondrial helicase Twinkle (DNT). DNT-expression depletes mitochondrial DNA during B cell maturation, reduces the abun...

2026-08-21 | MTBLS4647 | MetaboLights
MetabolomicsNano-formulated bisphosphonate adjuvants simultaneously induce humoral and cellular immunity
Adjuvant is an important component of vaccines However, given the limitation of existing adjuvants in variety and mechanism, developing a unique and effective adjuvant is urgently needed for clinal applications. Recent studies have implicated that the mevalonate pathway plays an essential role in va...
2026-03-03 | MTBLS11696 | MetaboLights
MetabolomicsMitochondrial respiration in B lymphocytes is essential for humoral immunity by controlling flux of the TCA cycle
Not available
ORGANISM(S): Mus musculus 
ST002140 | MetabolomicsWorkbench
ProteomicsProteomic analysis of humoral immune components in bronchoalveolar lavage of patients infected or colonized by Aspergillus fumigatus
Humoral immune factors have been individually studied in the context of host-Aspergillus fumigatus interaction. However, a global view of the multitude and complex nature of humoral factors is needed to bring new insight into the pathobiology of aspergillosis. Therefore, we undertook proteomic analy...
ORGANISM(S): Homo sapiens (Human) Aspergillus fumigatus Af293 
2021-08-11 | PXD023417 | Pride
Alveolar humoral factors Bronchoalveolar lavage Aspergillus fumigatus 
GenomicsGut microbiota composition impact humoral response to BNT16b2 in mice
Gut microbiota composition impact humoral response to BNT16b2 in mice
PRJEB103798 | ENA
GenomicsGut microbiota shape humoral responses to mRNA vaccines through metabolic remodeling
Gut microbiota shape humoral responses to mRNA vaccines through metabolic remodeling
PRJEB103086 | ENA
GenomicsGut microbiota shape humoral responses to mRNA vaccines through metabolic remodeling
Gut microbiota shape humoral responses to mRNA vaccines through metabolic remodeling
PRJEB100963 | ENA
ProteomicsLC-MS/MS EThcD of MERS-CoV and SARS-CoV S N-linked glycopeptides from recombinant spike ectodomains and whole MERS virions
Recent outbreaks of severe acute respiratory syndrome and Middle-East respiratory syndrome along with the threat of a future coronavirus pandemic underscore the importance of finding ways to neutralize these viruses. The trimeric spike transmembrane glycoprotein S mediates entry into host cells and ...
ORGANISM(S): Severe Acute Respiratory Syndrome-related Coronavirus (ncbitaxon:694009) Middle East Respiratory Syndrome-related Coronavirus (ncbitaxon:1335626) 
2020-03-13 | MSV000085097 | MassIVE
GenomicsMetabolic control of Tfh and humoral immunity by phosphatidylethanolamine
Metabolic control of Tfh and humoral immunity by phosphatidylethanolamine
PRJNA613290 | ENA
GenomicsCD40-induced humoral immunity
CD40-induced humoral immunity
PRJNA1441975 | ENA
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