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TranscriptomicsSLE lupus RNA-seq
RNA-seq of systemic lupus erythematosus (SLE) whole blood and healthy controls to determine the gene expression changes in these patients. RNA-seq of PAXgene blood from SLE and healthy donors.
ORGANISM(S): Homo sapiens 
2015-09-16 | E-GEOD-72509 | biostudies-arrayexpress
TranscriptomicsING4 ChIP-chip in HT1080 cells
Aberrations in chromatin dynamics play a fundamental role in tumorigenesis, yet relatively little is known of the molecular mechanisms linking histone lysine methylation to neoplastic disease. ING4 (Inhibitor of Growth 4) is a native subunit of an HBO1 histone acetyltransferase (HAT) complex and a t...
ORGANISM(S): Homo sapiens 
2010-05-17 | E-GEOD-13412 | biostudies-arrayexpress
TranscriptomicsCell cycle promoter tiling
Discover novel transcriptional units upstream of cell cycle genes Transcription of long noncoding RNAs (lncRNAs) within gene regulatory elements can modulate gene activity in response to external stimuli, but the scope and functions of such noncoding transcription are not known. Here we use an ultr...
ORGANISM(S): Homo sapiens 
2011-05-21 | E-GEOD-28631 | biostudies-arrayexpress
TranscriptomicsJade1 ChIP-chip on ENCODE Tiling array
Several MYST-family histone acetyltransferase (HAT) enzymes associate with specific ING tumor suppressor proteins. ING complexes containing the HBO1 HAT protein are the major source of histone H4 acetylation in vivo and have been shown to play critical roles in gene regulation and DNA replication. H...
ORGANISM(S): Homo sapiens 
2010-05-14 | E-GEOD-14309 | biostudies-arrayexpress
Transcriptomicsp53-dependent regulation of gene expression following DNA damage
Long noncoding RNAs (lncRNAs) are prevalent genes with frequently exquisite regulation but mostly unknown functions. Here we demonstrate a role of lncRNAs in guiding signal transduction. DNA damage activates transcription of DINO (Damage Induced NOncoding) via p53. DINO knockdown blocks DNA damage-i...
ORGANISM(S): Homo sapiens 
2012-11-20 | E-GEOD-42368 | biostudies-arrayexpress
UnknownPharmacokinetics of hydroxychloroquine in paediatric lupus: data from a novel, direct-to-family clinical trial.
Not available
S-EPMC9639143 | biostudies-literature
UnknownDelivering clinical trials at home: protocol, design and implementation of a direct-to-family paediatric lupus trial.
Not available
S-EPMC8108689 | biostudies-literature
UnknownHealth Equity Implications of Missing Data Among Youths With Childhood-Onset Systemic Lupus Erythematosus: A Proof-of-Concept Study in the Childhood Arthritis and Rheumatology Research Alliance Registry.
Not available
S-EPMC10593908 | biostudies-literature
UnknownImpact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries.
Not available
S-EPMC10783642 | biostudies-literature
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