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TranscriptomicsRNA-seq of livers from mice treated for eight weeks with the glucagon receptor antibody, REGN1193, compared to mice treated with a control antibody, REGN1945, (control group)
Chronic glucagon receptor inhibition with a glucagon receptor antibody decreases amino acid catabolism and ureagenesis, while increasing plasma triglyceride concentrations, plasma very-low density lipoprotein cholesterol concentrations, and liver triglyceride concentrations. To dissect the molecular...
ORGANISM(S): Mus musculus 
2022-10-09 | E-MTAB-12048 | biostudies-arrayexpress
UnknownQuantifying decision-making in dynamic, continuously evolving environments.
Not available
S-EPMC10602589 | biostudies-literature
UnknownCombinatorial approach for screening and assessment of multiple therapeutic enzymes from marine isolate Pseudomonas aeruginosa AR01.
Not available
S-EPMC9064559 | biostudies-literature
UnknownThe use of social prescribing and community-based wellbeing activities as a potential prevention and early intervention pathway to improve adolescent emotional and social development: a systematic mapping review.
Not available
S-EPMC12522731 | biostudies-literature
TranscriptomicsRNA-seq of livers from female mice treated for eight weeks with the glucagon analogue, NNC9204-0043, compared to female mice treated with PBS (control group)
Chronic glucagon receptor activation with a long-acting glucagon analogue increases amino acid catabolism, and to dissect the molecular mechanism underlying this effect, RNA sequencing of liver biopsies from female mice treated for eight weeks with GCGA or PBS were performed.
ORGANISM(S): Mus musculus 
2022-10-11 | E-MTAB-12040 | biostudies-arrayexpress
TranscriptomicsRNA-seq of livers from glucagon receptor knock-out (GcgrKO) mice compared to wildtype littermates
Glucagon is a key regulator of glucose homeostasis, amino acid catabolism, and lipid metabolism. Glucagon receptor knock-out (GcgrKO) mice have slightly reduced blood glucose levels whereas plasma levels of amino acids are vastly increased reflecting disruption of hepatic amino acid catabolism. To d...
ORGANISM(S): Mus musculus 
2022-10-11 | E-MTAB-12060 | biostudies-arrayexpress
GenomicsWTCCC2 Pharmacogenomic Response to Statins study
A WTCCC2 project genome-wide study for pharmacogenomic response to statins (PR) in individuals from Scotland.
EGAS00000000121 | EGA
ProteomicsInteractome of E1 ubiquitin-activating enzymes and of E2 ubiquitin-conjugating enzymes in human HEK293 cells.
Investigation of E1 ubiquitin-activating enzymes and E2 ubiquitin-conjugating enzymes interactome in human HEK293 cells.
ORGANISM(S): Homo sapiens (Human) 
2023-11-14 | PXD042361 | Pride
E1 ubiquitin-activating enzymes  e2 ubiquitin-conjugating enzymes  ubiquitin  human cells  interactome. 
UnknownApproaches to early intervention for common mental health problems in young people: a systematic review.
Not available
S-EPMC12642248 | biostudies-literature
GenomicsThe GENCODE exome sequencing the complete human exome
We report the design of an extended set of targets for capturing the complete human exome, based on annotation from the GENCODE consortium. The extended set covers an addition 5,594 genes and 10.3 Mb compared to current sets which mainly target the CCDS database. The additional regions include poten...
EGAS00001000016 | EGA
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