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TranscriptomicsTranscription profiling by array of mice lacking exons 3 to 4 of the Pgc1beta gene (PGC1beta E3,4-/E3,4- mice) against wild type controls to study the role of PGC1beta in metabolism
PGC1beta is a transcriptional coactivator that potently stimulates mitochondrial biogenesis and respiration of cells. Here, we have generated mice lacking exons 3 to 4 of the Pgc1beta gene (PGC1beta E3,4-/E3,4- mice). These mice express a mutant protein that has reduced coactivation activity on a su...
ORGANISM(S): Mus musculus 
2009-04-24 | E-GEOD-6210 | biostudies-arrayexpress
TranscriptomicsLiver adapts mitochondrial function to insulin-resistant and diabetic states in mice
Objective: To study if diabetic and insulin-resistant states lead to mitochondrial dysfunction in the liver, or alternatively, if there is adaption of mitochondrial function to these states in the long-term range. Results: High-fat diet (HFD) caused insulin resistance and severe hepatic lipid accum...
ORGANISM(S): Mus musculus 
2013-12-10 | E-GEOD-39752 | biostudies-arrayexpress
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