Huntington's disease

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Unknown (2868)
Genomics (351)
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Proteomics (60)
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Genomic (4)
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Organisms

Mus musculus (220)
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Arabidopsis thaliana (1)

Organisms

Mus musculus (123)
Homo sapiens (84)
Rattus norvegicus (6)
Canis lupus familiaris (1)
Ovis aries (1)
Drosophila melanogaster (1)
Saccharomyces cerevisiae (1)

Repository

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geo (211)
biostudies-arrayexpress (131)
pride (43)
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dbGaP (4)
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Tissue

Brain (21)
Cell culture (7)
Astroglial cell (2)
Astrocyte of the cerebral cortex (2)
Cerebrospinal fluid (2)
Neuron (2)
White adipose tissue around intestine (1)
White adipose tissue around gonad (1)
Hypothalamus and thalamus (1)
Gastrocnemius (1)
Corpus callosum (1)
Brainstem (1)
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Skin (1)
Hippocampus (1)
Heart (1)
Cerebellum (1)
Striatum (1)
Hypocotyl (1)
Neuroblastoma cell line (1)
HiPSC cell (1)
HEK-293T cell (1)
Olfactory bulb (1)
Electrically active cell (1)
Extracellular vesicle (1)
Cotyledon (1)
Early embryonic cell (1)
Blood plasma (1)
Root (1)
Stem cell (1)

Disease

Huntington Disease (32)
Huntington's disease (3)
Parkinson's disease (3)
Alzheimer's disease (2)
Normal (2)
Cerebral degeneration (1)
Retinal degeneration (1)
Ocular albinism (1)
Retinal disease (1)
Retinal detachment (1)
Huntington's disease mouse model (1)
Pheochromocytoma (1)
Melanoma (1)
Not Available (1)
Influenza (1)
COVID-19 (1)

Technology Type

Mass Spectrometry (43)
Shotgun proteomics (31)
Bottom-up proteomics (7)
Affinity purification coupled with mass spectrometry proteomics (7)
Data-dependent acquisition (6)
Data-independent acquisition (4)
HiSeq X Ten, ILLUMINA (2)
Mass spectrometry (1)
Mass spectrometry assay (1)
SWATH MS (1)
Gel-based experiment (1)
Top-down proteomics (1)
Chemical cross-linking coupled with mass spectrometry proteomics (1)

Instrument Platform

Q Exactive (4)
Illumina NovaSeq 6000 (3)
Orbitrap Fusion (3)
Orbitrap Fusion Lumos (2)
Chromium 10xGenomics (1)
Agilent G2565CA Microarray Scanner System (1)
R (1)
Illumina HiSeq 2000 (1)
- (1)
Instrument (1)
Q-Exactive HF-X (1)
Thermo Scientfic LTQ-Orbitrap-Elite MS (1)
ABSciex 5600 (1)
TimsTOF Ultra (1)
Orbitrap Eclipse (1)
Q Exactive HF (1)
Exactive (Thermo Scientific) (1)
Liquid Chromatography MS - positive - reverse-phase (1)
Liquid Chromatography MS - negative - reverse-phase (1)
Liquid Chromatography MS - positive - reverse phase (1)

Publication Date

2016 (51)
2025 (38)
2015 (31)
2014 (28)
2024 (24)
2017 (23)
2013 (21)
2022 (21)
2020 (21)
2018 (19)
2021 (18)
2008 (16)
2023 (16)
2026 (15)
2012 (15)
2019 (14)
2010 (14)
2007 (10)
2011 (8)
2005 (4)
2009 (3)
2004 (1)

CHEBI ID

CHEBI:74236 (1)
CHEBI:60425 (1)
CHEBI:23888 (1)
CHEBI:60027 (1)
CHEBI:11951 (1)
CHEBI:18401 (1)
CHEBI:21560 (1)
CHEBI:73040 (1)
CHEBI:27584 (1)
CHEBI:27551 (1)
CHEBI:30660 (1)
CHEBI:30762 (1)
CHEBI:17489 (1)
CHEBI:17781 (1)
CHEBI:18243 (1)
CHEBI:28171 (1)
CHEBI:40992 (1)
CHEBI:17311 (1)
CHEBI:16962 (1)
CHEBI:16827 (1)
CHEBI:15765 (1)
CHEBI:15318 (1)
CHEBI:17287 (1)
CHEBI:16296 (1)
CHEBI:73024 (1)
CHEBI:16680 (1)
CHEBI:16335 (1)
CHEBI:16708 (1)
CHEBI:16450 (1)
CHEBI:16737 (1)

Metabolite Name

CYCLIC AMP (1)
O-SUCCINYL-HOMOSERINE (1)
DHEAS (1)
5-HYDROXYTRYPTOPHAN (1)
4-QUINOLINECARBOXYLATE (1)
PHENYLACETATE (1)
THYROXINE (1)
S-ADENOSYLHOMOCYSTEINE (1)
GLUTARYLCARNITINE (1)
PHOSPHOCREATINE (1)
4-ACETAMIDOBUTANOATE (1)
(5S)-3-(2-aminoethylsulanyl)-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (1)
S-acetyldihydrolipoamide (1)
N-(3-Aminopropyl)-4-methyl-2-nitrobenzenamine (1)
Procyanidin A1 (1)
Glycine linoleate (1)
Tert-Butoxycarbonylasparagine (1)
Acridine-9-amine (1)
4-Hydroxytiglic acid (1)
Oryzalexin E (1)
2',3'-DIDEOXYCYTIDINE (1)
Cysteinyl-glutamate (1)
Ethyl fumarate (1)
N-ethylene glycol neuraminic acid (1)
(¡À)19(20)-EpDPE(A) (1)
1-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine (1)
1-Palmitoyl-2-oleoyl-sn-glycero-3-(phospho-rac-(1-glycerol)) (1)
(¡À)8-HETE (1)
L-DOPA (1)
(1S,4aS,7aS)-7-(hydroxymethyl)-1-[(2R,3S,4R,5R,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylic acid (1)

First Public Date

2025 (44)
2014 (31)
2016 (28)
2024 (27)
2020 (25)
2018 (20)
2026 (18)
2022 (18)
2021 (18)
2017 (16)
2023 (12)
2015 (11)
2013 (10)
2019 (5)

Modelling Approach

Ordinary differential equation model (4)

Study status

Recruiting (1)

Lab affiliation

Christoph Schaab (3)
Evotec, Martinsried, Germany (3)
Dept of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Sweden (2)
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, United States (1)
Department of Molecular Biology, Princeton University,USA (1)
Evotec (1)
NNF CPR, Copenhagen Univeristy, Denmark (1)
University of Melbourne, Florey Institute (1)
Department of Genome Engineering, Institute of Bioorganic Chemistry Polish Academy of Sciences, Poznan, 61-704, Poland (1)
Professor Cellular Imaging, PI Huntington degradation research groupleader, Department of Medical Biology, Amsterdam UMC location AMC, Amsterdam, The Netherlands (1)
Institute for Genetics and Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD) University of Cologne Joseph Stelzmann Strasse 26 50931 Cologne, Germany Phone number: +49 22147884172 Fax number: +49 221 478 84045 E-mail: dvilchez@uni-koeln.de (1)
Sherbrooke University, Immunology and cellular biology department, FMSS (1)
Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82159 Martinsried, Germany (1)
Evotec (Munchen) GmbH, Am Klopferspitz 19a, 82152 Martinsried, Germany ( lab head ) (1)
Evotec (München) GmbH Anna-Sigmund-Str. 5 82061 Neuried Germany (1)
Dept. Biomedical Sciences, Institute of Neurosciences, School of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain (1)
University of Campinas - São Paulo - Brazil (1)
Dept. Biomedical Sciences, Institute of Neurosciences, School of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain (1)
Christoph Schaab, Evotec (1)
Faculty Scientist,Institute of Bioinformatics, International Technology Park, Bangalore 560066, India (1)
Laboratory of Applied Proteome Analyses, Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, Libechov, Czech Republic (1)
Faculty of Health Sciences, Department of Proteomics, The Novo Nordisk Foundation Centre for Protein Research, University of Copenhagen, DK-2200 Copenhagen, Denmark (1)
Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany Department of Proteomics and Signal Transduction (1)
Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Padualaan 8, Utrecht 3584 CH The Netherlands Netherlands Proteomics Center, Padualaan 8, Utrecht 3584 CH, The Netherlands (1)
Institute of Structural and Molecular Biology, University College London, London, United Kingdom (1)
University of Cologne, Germany (1)
Department of Biochemistry and Molecular Biology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010. Australia (1)
CECAD Forschungszentrum, Joseph-Stelzmann-Str. 26, 50931 Köln (1)
Chan Zuckerberg Biohub (1)
Department of Molecular Biology, Princeton University, USA (1)

Keyword

Diabete Mellitus (1)
Sickle Cell Disease (1)
Sjogren’s Syndrome (1)

IsPrivate

False (4)

Model Flag

Non Kinetic (1)

Study type

Transcription profiling by array (69)
RNA-seq of coding RNA (31)
ChIP-seq (13)
RNA-seq of non coding RNA (8)
Transcription profiling by SAGE (2)
Genotyping by array (2)
Methylation profiling by array (2)
Methylation profiling by high throughput sequencing (2)
Unknown experiment type (1)
RNA-seq of coding RNA from single cells (1)
Observational (1)

Release Date

2022 (310)
2021 (275)
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2020 (220)
2019 (194)
2017 (183)
2018 (176)
2016 (173)
2015 (161)
2014 (125)
2013 (95)
2012 (95)
2011 (67)
2010 (57)
2008 (40)
2009 (37)
2026 (27)
2007 (21)
2005 (12)
2006 (12)
2003 (10)
2004 (5)
2002 (5)
2001 (3)
1999 (2)
1996 (1)
1993 (1)
1989 (1)

Location

United States (1)

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Human blood expression for Huntington's disease versus control

Affymetrix U133A expression levels for 12 symptomatic and 5 presymptomatic Huntington's disease patients versus 14 healthy controls. Keywords: other

ORGANISM(S): Homo sapiens

2005-09-13 | E-GEOD-1751 | biostudies-arrayexpress

Alterations in the tyrosine and phenylalanine pathways revealed by biochemical profiling in cerebrospinal fluid of Huntington’s disease subjects

Huntington's disease (HD) is a severe neurological disease leading to psychiatric symptoms, motor impairment and cognitive decline. The disease is caused by a CAG expansion in the huntingtin (HTT) gene, but how this translates into the clinical phenotype of HD remains elusive. Using liquid chromatog...

2019-06-21 | MTBLS749 | MetaboLights

Depletion of p62 reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington's model mice

Huntington's disease (HD) is a dominantly inherited genetic disease caused by mutant huntingtin (htt) protein with expanded polyglutamine tracts. A neuropathological hallmark of HD is the presence of neuronal inclusions of mutant htt. p62 is an important regulatory protein in selective autophagy, ...

ORGANISM(S): Mus musculus

2014-10-10 | E-GEOD-62210 | biostudies-arrayexpress

The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice

Transcriptional dysregulation has emerged as a core pathologic feature of Huntington's disease (HD), one of several triplet-repeat disorders characterized by movement deficits and cognitive dysfunction. Although the mechanisms contributing to the gene expression deficits remain unknown, therapeutic ...

ORGANISM(S): Mus musculus

2010-12-27 | E-GEOD-26317 | biostudies-arrayexpress

Huntington's disease biomarker progression profile identified by transcriptome sequencing in peripheral blood

In this study we investigated the suitability of blood to identify HD transcriptomic biomarkers, validated the outcome in an independent cohort and derived a first empiric panel of biomarkers capable of predicting HD motor scores. Finally we examined whether patient gene expression profiles could pr...

ORGANISM(S): Homo sapiens

2015-02-02 | E-GEOD-51799 | biostudies-arrayexpress

HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation

Increasing evidence has demonstrated that epigenetic factors can profoundly influence gene expression and, in turn, influence resistance or susceptibility to disease. Epigenetic drugs, such as histone deacetylase (HDAC) inhibitors, are finding their way into clinical practice, although their exact m...

ORGANISM(S): Homo sapiens

2015-04-10 | E-GEOD-67733 | biostudies-arrayexpress

Targeting H3K4 methylation as a therapeutic strategy for Huntington's disease (ChIP-seq)

Transcriptional dysregulation is an early feature of Huntington's disease (HD). We observed gene-specific changes in H3K4me3 at transcriptionally repressed promoters in R6/2 mouse and human HD brain. Genome-wide analysis showed a novel chromatin signature for this mark. Reducing the levels of the H3...

ORGANISM(S): Mus musculus

2013-07-18 | E-GEOD-48960 | biostudies-arrayexpress

Targeting H3K4 methylation as a therapeutic strategy for Huntington's disease (RNA-seq)

ORGANISM(S): Mus musculus

2013-07-18 | E-GEOD-48962 | biostudies-arrayexpress

The transcriptional modulator H2AFY marks Huntington's disease activity in men and mice

To accelerate the development of disease-modifying therapeutics for Huntington’s disease (HD), a dynamic biomarker of disease activity and treatment response is critically needed. Venous cellular whole blood from 8 patients with Huntington's disease (HD) and 6 control subjects were collected in PAXg...

ORGANISM(S): Homo sapiens

2011-09-01 | E-GEOD-24250 | biostudies-arrayexpress

Huntington's Disease Clinical Trials Corner: August 2023.

Not available

S-EPMC10473124 | biostudies-literature

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