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ProteomicsInternally Tagged Ubiquitin: a Tool to Identify Linear Polyubiquitin-modified Proteins by Mass Spectrometry
Even though ubiquitination controls a plethora of cellular processes, modifications by linear polyubiquitin have so far only been linked with acquired and innate immunity, lymphocyte development and genotoxic stress response. Until now, a single E3 ligase complex (LUBAC), one specific deubiquitinase...
ORGANISM(S): Homo sapiens (Human) 
2017-03-21 | PXD005878 | Pride
Ubiquitin Proteomics Human Pull-down 
ProteomicsN4BP1 is a unique, dimerization-dependent linear ubiquitin reader that regulates TNFR1 signalling through linear ubiquitin binding and Caspase-8-dependent processing
Signalling through TNFR1 modulates proinflammatory gene transcription and programmed cell death, and its impairment causes autoimmune diseases and cancer. NEDD4 binding protein 1 (N4BP1) was recently identified as a critical suppressor of proinflammatory cytokine production1, whose mode of action re...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD024355 | Pride
Caspase 8 Proteolytic processing N4bp1 
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