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TranscriptomicsHuman-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion
The evolutionary expansion of the human neocortex reflects increased amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. Here, we analyze the transcriptomes of distinct progenitor subpopulations isolated by a novel approach from developi...
ORGANISM(S): Homo sapiens 
2015-03-02 | E-GEOD-65000 | biostudies-arrayexpress
TranscriptomicsNeural stem and progenitor cells shorten S-phase upon commitment to neuron production
The dorsal telencephalon from E14.5 Tis21–GFP heterozygous mice embryos was subjected to microarray analysis. To identify genes whose expression were changed in Tis21–GFP positive S phase cells compared to Tis21–GFP negative S phase cells, Tis21–GFP positive or negative S phase cells labeled with a ...
ORGANISM(S): Mus musculus 
2010-11-30 | E-GEOD-23585 | biostudies-arrayexpress
TranscriptomicsTranscriptomes of germinal zones of human and mouse fetal neocortex suggest a role of extracellular matrix in progenitor self-renewal.
The expansion of the neocortex during mammalian brain evolution results primarily from an increase in neural progenitor cell divisions in its two principal germinal zones during development, the ventricular zone (VZ) and the subventricular zone (SVZ). Using mRNA sequencing, we analyzed the transcrip...
ORGANISM(S): Homo sapiens 
2012-07-02 | E-GEOD-38805 | biostudies-arrayexpress
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