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MetabolomicsHyperoxia induces glutamine-fuelled anaplerosis in retinal Müller cells
Premature infants require oxygen supplementation to survive, but excess oxygen causes retinovascular growth suppression that underlies the leading cause of infant blindness known as retinopathy of prematurity (ROP). We analyzed changes in intermediary metabolism during hyperoxia in human retinal end...
2020-03-12 | MTBLS1228 | MetaboLights
MetabolomicsBaby Mice Hyperoxia treatment (G64-N.H-7d14d)
Not available
ORGANISM(S): Mus musculus 
ST000169 | MetabolomicsWorkbench
TranscriptomicsGene regulation in the hyperoxia mouse retina
PURPOSE: Hyperoxia is toxic to photoreceptors, and this toxicity may be important in the progress of retinal dystrophies. This microarray study examines gene expression induced in the C57BL/6J mouse retina by hyperoxia over the 14-day period during which photoreceptors first resist, then succumb to,...
ORGANISM(S): Mus musculus 
2010-08-05 | E-GEOD-23437 | biostudies-arrayexpress
TranscriptomicsAffymetrix array of postnatal day 4 mouse atria exposed to room air or hyperoxia
It is unclear why preterm birth increases risk of cardiovascular disease later in life. Studies in mice indicate excess oxygen typically used to treat preterm infants causes pulmonary hypertension, cardiac failure, and shortens lifespan. We previously reported neonatal hyperoxia causes pulmonary hyp...
ORGANISM(S): Mus musculus 
2021-02-23 | E-MTAB-9008 | biostudies-arrayexpress
TranscriptomicsExpression data from 8-10 week old WT mice maintained in room air or exposed to hyperoxia (FiO2>95%) for 48 hrs
To detect sex-specific differences in gene expression in a model of hyperoxic lung injury in adult C56BL/6J mice. In this dataset, we include the expression data obtained from lungs from 8-10 week old male and female WT C57BL/6J mice exposed to hyperoxia for 48 hours amd room air controls.These data...
ORGANISM(S): Mus musculus 
2014-12-10 | E-GEOD-51039 | biostudies-arrayexpress
TranscriptomicsGene expression profiles in AEC II during hyperoxia exposure and recovery
In this study, type II alveolar epithelial cells (AEC II) were isolated from normal, hyperoxia exposed (day 0) and recovery (day 1,3,5 and 7) rats with high purity (~95%). Total RNA from isolated cells were used for dual color DNA microarray hybridization with 3DNA 50 kit version 2. Keywords: time-c...
ORGANISM(S): Rattus norvegicus 
2010-06-11 | E-GEOD-2707 | biostudies-arrayexpress
ProteomicsSIRT3 Deficiency Drives Alveolar Epithelial Mitochondrial Dysfunction in Hyperoxia-Induced Bronchopulmonary Dysplasia via PDHA1 Hyperacetylation
Neonates were pooled and randomized at P0 to circumvent litter bias and subjected to either normoxia or hyperoxia (85% O2) for 14 days.
ORGANISM(S): Mus musculus (Mouse) 
2026-06-02 | PXD078668 | Pride
Bronchopulmonary dysplasia  pdha1  sirt3  hyperacetylation 
GenomicsNeonatal mouse exposed to hyperoxia
Neonatal mouse exposed to hyperoxia
PRJNA531182 | ENA
TranscriptomicsDifferential gene expression in mouse retina related to regional differences in vulnerability to hyperoxia
Purpose: In the C57BL/6J mouse retina, hyperoxia-induced degeneration of photoreceptors shows strong regional variation, beginning at a locus ~0.5mm inferior to the optic disc. To identify gene expression differences that might underlie this variability in vulnerability, we have used microarray tech...
ORGANISM(S): Mus musculus 
2010-04-08 | E-GEOD-21246 | biostudies-arrayexpress
ProteomicsRegulation of hyperoxia-induced neonatal lung injury via posttranslational cysteine redox modifications
Lung tissue from normoxia- or hyperoxia-treated control or SCNN1B overexpression mice were processed with a redox proteomics workflow and analyzed by LC-MS/MS with TMT based quantification. Data was searched with MS-GF+ using PNNL's DMS Processing pipeline.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-08-18 | MSV000090157 | MassIVE
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