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TranscriptomicsExpression data from male and female Schlager hypertensive (BPH/2J) and normotensive (BPN/3J) kidneys
Analysis of kidneys from 12 week BPH/2J hypertensive and age matched normotensive BPN/3J controls - males and females. The results provide insights into the genes that are involved in hypertension in both males and females, as well as highlight mechanisms that underlye sex differences in hypertensio...
ORGANISM(S): Mus musculus 
2014-09-28 | E-GEOD-54015 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of feft ventricle in three genetic rat models of hypertension
Left ventricle gene expression was analyzed in three models of hypertension in order to clarify the molecular mechanisms associated with left ventricular hypertrophy. Transgenic heterozygous TGR(mRen2)27 rats, overexpressing the mouse renin gene, and their littermate negative controls, spontaneously...
ORGANISM(S): Rattus norvegicus 
2006-08-31 | E-MEXP-357 | biostudies-arrayexpress
TranscriptomicsAdrenal gland gene expression from adult (12-week old) hypertensive BPH and adult (12-week old) hypotensive BPL mice
The objective of the experiment is to determine the genes differentially expressed in the adrenal gland of adult (12-week) BPH and BPL mice. Adrenal glands from adult (12-week) hypertensive BPH mice (n=3) and adult (12-week) hypotensive BPL mice (n=3).
ORGANISM(S): Mus musculus 
2010-06-16 | E-GEOD-19342 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat adrenal glands from spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto animals
We measured gene expression in the adrenal glands of the Spontaneously Hypertensive Rat (SHR) and Wistar-Kyoto rat (WKY) using Affymetrix RG-U34A GeneChips. All rats were aged-matched at 4-weeks. The rats were obtained from the colonies at the Univeristy of California San Diego, La Jolla, CA.
ORGANISM(S): Rattus norvegicus 
2007-11-01 | E-GEOD-1675 | biostudies-arrayexpress
TranscriptomicsEffect of Hypertension of Dendritic Cell Gene Expression
Oxidative injury and inflammation have been implicated in the genesis of hypertension but the mechanisms involved are not fully understood. We describe a new pathway in which angiotensin II promotes dendritic cell (DC) activation of T cells and ultimately hypertension. NADPH oxidase-dependent super...
ORGANISM(S): Mus musculus 
2014-07-16 | E-GEOD-59422 | biostudies-arrayexpress
ProteomicsDeacetylation of Septin4 by NAD-dependent deacetylase SIRT2 mitigates damaging effects of hypertensive nephropathy
RATIONALE: Hypertension can lead to podocyte damage and subsequent apoptosis, eventually resulting in glomerulosclerosis. Although alleviating podocyte apoptosis has clinical significance for the treatment of hypertensive nephropathy, an effective therapeutic target has not yet been identified. The ...
ORGANISM(S): Mus Musculus 
2022-12-05 | PXD038538 |
TranscriptomicsCaMKII inhibition in smooth muscle cells controls Ang-II-induced gene transcription in the aorta
The Ca2+/calmodulin-dependent kinase II is expressed in smooth muscle and believed to mediate intracellular calcium handling and calcium-dependent gene transcription. CaMKII is activated by Angiotensin-II. The multifunctional calcium/calmodulin-dependent kinase II (CaMKII) is activated by Angiotensi...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-64613 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse adrenal glands of the BPH hypertensive and BPL hypotensive mouse strains
We performed Affymetrix MG-U74Av2 GeneChip experiements on mRNA from the adrenal glands of the BPH hypertensive and BPL hypotensive mouse strains. All mice were aged-matched at 5 weeks. We obtained the mice from Jackson Laboratories, Bar Harbor, ME.
ORGANISM(S): Mus musculus 
2007-10-12 | E-GEOD-1674 | biostudies-arrayexpress
GenomicsPost-Stroke Learning Impairment and Brain Hemorrhage are Augmented in Hypertensive Mice
Post-Stroke Learning Impairment and Brain Hemorrhage are Augmented in Hypertensive Mice
PRJNA1040322 | ENA
GenomicsPodocytes from Hypertensive and Obese Mice Acquire an Inflammatory, Senescent and Aged Phenotype
Podocytes from Hypertensive and Obese Mice Acquire an Inflammatory, Senescent and Aged Phenotype
PRJNA1076227 | ENA
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