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MetabolomicsMyocardial-intrinsic defects underlie an Rbfox-mediated zebrafish model of hypoplastic left heart syndrome
Hypoplastic left heart syndrome (HLHS) is characterized by underdevelopment of left sided structures including the ventricle, valves, and aorta1. Although the mechanisms of disease pathogenesis remain elusive due to a paucity of candidate genes and animal models, prevailing paradigm suggests that HL...
2022-07-12 | MTBLS4176 | MetaboLights
TranscriptomicsIdentification of Copy Number Variants in Patients with Hypoplastic Left Heart Syndrome and Other Congenital Heart Defects
Hypoplastic left heart syndrome (HLHS) is a heterogeneous, lethal combination of congenital malformations that result in a heart unable to sustain systemic circulation. The genetic determinants of this disorder are largely unknown. Evidence of copy number variants (CNVs) contributing to the genetic ...
ORGANISM(S): Homo sapiens 
2015-12-10 | E-GEOD-66032 | biostudies-arrayexpress
TranscriptomicsRNA-seq of fetal lamb heart treated with coiled implantation in left atrium against untreated controls
We created a fetal lamb model of hypoplastic left heart syndrome (HLHS), by implanting coils in the left atrium in mid-gestation. We performed bulk RNA sequencing of left ventricles (LV), right ventricles (RV), ascending aortae (AAo) and pulmonary arteries (PA). Single nucleus RNA sequencing was per...
ORGANISM(S): Ovis aries 
2023-05-31 | E-MTAB-12327 | biostudies-arrayexpress
TranscriptomicsmicroRNA profiling of fetal lamb heart treated with coiled implantation in left atrium against untreated controls
We created a fetal lamb model of hypoplastic left heart syndrome (HLHS), by implanting coils in the left atrium in mid-gestation. We performed bulk RNA sequencing of left ventricles (LV), right ventricles (RV), ascending aortae (AAo) and pulmonary arteries (PA). Single nucleus RNA sequencing was per...
ORGANISM(S): Ovis aries 
2023-05-31 | E-MTAB-12230 | biostudies-arrayexpress
ProteomicsSequential defects in cardiac lineage commitment and maturation cause hypoplastic left heart syndrome
Complex molecular programs in specific cell lineages govern human heart development. Hypoplastic left heart syndrome (HLHS) is the most severe congenital heart defect encompassing a spectrum of left-ventricular hypoplasia occurring in association with outflow-tract obstruction. The current clinical ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD014812 | Pride
Hypoplastic left heart syndrome 
TranscriptomicsIdentifying gene expression profiles in hypoplastic left heart syndrome and age-matched normal controls
Affymetrix GeneChip Exon-1.0ST was used to study the differential gene profiles in RV (right ventricle) samples from neonates with HLHS (hypoplastic left heart syndrome) versus RV and LV (left ventricle) samples obtained from age-matched controls. Although few significant changes were observed in th...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-23959 | biostudies-arrayexpress
GenomicsGenetic Etiology of Hypoplastic Left Heart Syndrome (HLHS)
Genetic Etiology of Hypoplastic Left Heart Syndrome (HLHS)
PRJNA356955 | ENA
GenomicHypoplastic Left Heart Syndrome Study

To understand the genetic etiology of hypoplastic left heart syndrome (HLHS), patients with HLHS were consented and recruited, with blood drawn for DNA extraction and exome sequencing. Using the exome sequencing dataset obtained, rare coding sequence variants were recovered and enrichment analysi...

phs001256 | dbGaP
GenomicsThe complex genetics of hypoplastic left heart syndrome
The complex genetics of hypoplastic left heart syndrome
PRJNA311577 | ENA
GenomicsHypoplastic Left Heart Syndrome Single Cell RNA Sequencing
Hypoplastic Left Heart Syndrome Single Cell RNA Sequencing
PRJNA611831 | ENA
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