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TranscriptomicsHypoxia-independent downregulation of hypoxia inducible factor 1 targets by androgen deprivation therapy in prostate cancer.
Hypoxia inducible factor 1 (HIF1) has been shown to cooperate with the androgen receptor (AR) in activation of oncogenic pathways in prostate cancer (PCa). Here we hypothesized that HIF1 also plays a role in PCa response to androgen deprivation therapy (ADT). Comparison of gene expression profiles o...
ORGANISM(S): Homo sapiens 
2013-10-02 | E-GEOD-42868 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human U251 cells treated with hypoxia inducible factor HIF-1I siRNA or a polyamide targeted against the hypoxia response element (HRE) after induction of hypoxia
Transcription mediated by hypoxia inducible factor (HIF-1) contributes to tumor angiogenesis and metastasis but is also involved in the activation of cell-death pathways and normal physiological processes. Given the complexity of HIF-1 signaling it could be advantageous to target a subset of HIF-1 ...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7835 | biostudies-arrayexpress
TranscriptomicsSHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors
Triple Negative Breast cancer accounts for some of the most aggressive types of breast cancer. By interrogating clinical datasets, we found that the activities of p63 and Hypoxia-Inducible-Factors (HIFs), two master regulators of the invasive and metastatic cancer cell phenotype are linked in TNBC ...
ORGANISM(S): Homo sapiens 
2012-07-18 | E-GEOD-33950 | biostudies-arrayexpress
GenomicsHypoxia inducible factors individually facilitate inflammatory myeloid metabolism and inefficient cardiac repair
Hypoxia inducible factors individually facilitate inflammatory myeloid metabolism and inefficient cardiac repair
PRJNA749066 | ENA
GenomicsHypoxia-inducible PRMT2 addiction in cancers
Hypoxia-inducible PRMT2 addiction in cancers
PRJNA986065 | ENA
MetabolomicsResting natural killer cell homeostasis relies on tryptophan/NAD+ metabolism and HIF-1α

Natural killer (NK) cells are forced to cope with different oxygen environments even under resting conditions. The adaptation to low oxygen is regulated by oxygen-sensitive transcription factors, the hypoxia-inducible factors (HIFs). The function of HIFs for NK cell activation and metabolic rewir...

2023-06-01 | MTBLS6863 | MetaboLights
GenomicsDNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumour immunotolerance [BS]
DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumour immunotolerance [BS]
PRJNA638592 | ENA
GenomicsDNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumour immunotolerance [ChIPBS]
DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumour immunotolerance [ChIPBS]
PRJNA338261 | ENA
GenomicsDNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumour immunotolerance [RNA]
DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumour immunotolerance [RNA]
PRJNA338259 | ENA
GenomicsDNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumour immunotolerance [ChIPSeq]
DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumour immunotolerance [ChIPSeq]
PRJNA338258 | ENA
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